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EC number: 701-289-2
CAS number: -
Oneda et al. 1994 found no tumorigenic effects in mice exposed to aluminum potassium sulfate.
DSD: not classified
CLP: not classified
Oneda et al. 1994 exposed B6C3F1 mice to
aluminium potassium sulphate in the diet in a 20 -month chronic toxicity
and tumorigenicity study. The dose levels used in the chronic study were
10% (w/w in the diet), 5.0%, 2.5% and 1.0% administered for a period of
20 months. These dose levels were chosen based on results from a
preliminary acute toxicity study. An earlier acute toxicity study by the
same investigators found an oral LD50 of 3672.5 mg/kg bw in males and
4400.9 mg/kg bw in females. Food consumption, growth, organ weight and
histopathology were examined in 60 mice per dose-sex category. The level
of aluminium in the basal diet was not reported nor the actual food
consumption. The highest dose administered corresponded to 979 mg Al/kg
bw/day [ATSDR (Agency for Toxic Substances and Disease Registry),
Toxicological Profile for Aluminum, Atlanta, GA. US Department of Health
and Human Services 2008].
All groups of APS treated mice tended to
have increased survival rates relative to the controls. The incidence of
tumors in the lower dose groups (1.0 -5.0% w/w) in both males and
females was not significantly different from the controls. In the
highest dose group (10% w/w), the tumor rate was significantly lower,
particularly in males. The liver cancer rate was 5.3% in this dose group
in males compared with 20.5% in the control group. Of interest was the
difference in rates of liver cancer in males compared to females in the
control and lower dose groups. Rates were higher in males for all 4
doses including controls. This study provides evidence for an absence of
an tumorigenic effect.
Systemic carcinogenic effects from exposure
specifically to aluminium or its compounds have not been investigated in
epidemiological studies. The overall available data from human and
animal studies provide no clear evidence for systemic carcinogenic
effects on exposure to aluminium [ATSDR (Agency for Toxic Substances and
Disease Registry), Toxicological Profile for Aluminum, Atlanta, GA. US
Department of Health and Human Services 2008] and [Krewski D, Yokel RA,
Nieboer E et al. Human health risk assessment for aluminium, aluminium
oxide and aluminium hydroxide. J Toxicol Environ Health Part B 2007; 10:
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