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EC number: 701-289-2 | CAS number: -
- Life Cycle description
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- Ecotoxicological Summary
- Aquatic toxicity
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- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February 2010
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ICCVAM Test Method Evaluation Report: Appendix G: ICCVAM Recommended Protocol for Future Studies Using the Hen’s Egg Test-Chorionallantoic Membrane (HET-CAM) Test method, November 2006.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- dioxo-2,4-dioxa-1,5-dialumina-3-magnesapentane oxomagnesium alumane
- EC Number:
- 701-289-2
- Molecular formula:
- Al, MgO, Mg(AlO2)2
- IUPAC Name:
- dioxo-2,4-dioxa-1,5-dialumina-3-magnesapentane oxomagnesium alumane
- Details on test material:
- - Name of test material (as cited in study report): Aluminium-Skimmings
- Physical state: grey solid
- Analytical purity: Aluminium: 708.0 g/kg
Ammonium(NH4): 22.0 g/kg
Magnesium: 68.0 g/kg
- Lot/batch No.: Lieferung vom 21.04.2009
- Stability under test conditions: until August 21, 2011
- Storage condition of test material: room temperature
Constituent 1
Test animals / tissue source
- Details on test animals or tissues and environmental conditions:
- The fertile Lohmann Brown extra hen eggs (Brinkschulte Josef GmbH & Co.KG, 48308 Senden) were incubated in an incubator with an automatic rotating device (e.g. Ehret GmbH), optimum temperature : 37.5 °C, relative humidity 63%.
After 7 days of incubation, all eggs were candled in order to discard those that were defect and to mark the air bubble. The eggs were replaced into the incubator with the large end upward but not rotated, thus ensuring accessibility to the CAM region.
At day 8 of incubation the sections marked for the air bubble were sawed out of the shell. The inner membrane was moistened with NaCl 0.9 % and carefully removed with forceps. Only eggs with normally developed embryos and blood vessel systems were used for testing.
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 300 mg per egg
- Duration of treatment / exposure:
- 300 seconds
- Observation period (in vivo):
- 300 seconds
- Number of animals or in vitro replicates:
- 4 eggs were used
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 300 sec
- Score:
- 0
- Max. score:
- 21
- Remarks on result:
- other: test substance
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 300 sec
- Score:
- 0
- Max. score:
- 21
- Remarks on result:
- other: negative control (saline)
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 300 sec
- Score:
- 10
- Max. score:
- 21
- Remarks on result:
- other: positive control (1% SDS)
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- Aluminium skimmings have no eye irritation potential based on the results of this HETCAM test.
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