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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available

Data source

Reference
Reference Type:
publication
Title:
Skin Absorption and Hippocampal Bioaccumulation of Water Soluble Aluminium Chloride in Mice
Author:
Anane, R. et al.
Year:
1995
Bibliographic source:
Human & Experimental Toxicology

Materials and methods

Objective of study:
absorption
Principles of method if other than guideline:
Aluminium skin absorption was investigated in mice.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Aluminium chloride
EC Number:
231-208-1
EC Name:
Aluminium chloride
Cas Number:
7446-70-0
IUPAC Name:
aluminum trichloride
Details on test material:
- Name of test material (as cited in study report): aluminium chloride
- Analytical purity: no data
Radiolabelling:
no

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: percutaneous
Vehicle:
not specified
Duration and frequency of treatment / exposure:
ervery day for 130 days
Doses / concentrations
Remarks:
Doses / Concentrations:
0.1 and 0.4 μg
No. of animals per sex per dose / concentration:
no data
Control animals:
not specified

Results and discussion

Preliminary studies:
no data

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Skin exposure to aluminium chloride produced a significant increase (p<0.05) of aluminium accumulation in the brain, especially in the hippocampal area. This finding was confirmed by microanalysis on slices of hippocampus showing accumulation of aluminium silicates.
Details on distribution in tissues:
not determined
Details on excretion:
not determined

Metabolite characterisation studies

Metabolites identified:
not measured

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): high bioaccumulation potential based on study results