Registration Dossier
Registration Dossier
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EC number: 701-289-2 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available
Data source
Reference
- Reference Type:
- publication
- Title:
- Skin Absorption and Hippocampal Bioaccumulation of Water Soluble Aluminium Chloride in Mice
- Author:
- Anane, R. et al.
- Year:
- 1 995
- Bibliographic source:
- Human & Experimental Toxicology
Materials and methods
- Objective of study:
- absorption
- Principles of method if other than guideline:
- Aluminium skin absorption was investigated in mice.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Aluminium chloride
- EC Number:
- 231-208-1
- EC Name:
- Aluminium chloride
- Cas Number:
- 7446-70-0
- IUPAC Name:
- aluminum trichloride
- Details on test material:
- - Name of test material (as cited in study report): aluminium chloride
- Analytical purity: no data
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: percutaneous
- Vehicle:
- not specified
- Duration and frequency of treatment / exposure:
- ervery day for 130 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 and 0.4 μg
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
Results and discussion
- Preliminary studies:
- no data
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Skin exposure to aluminium chloride produced a significant increase (p<0.05) of aluminium accumulation in the brain, especially in the hippocampal area. This finding was confirmed by microanalysis on slices of hippocampus showing accumulation of aluminium silicates.
- Details on distribution in tissues:
- not determined
- Details on excretion:
- not determined
Metabolite characterisation studies
- Metabolites identified:
- not measured
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): high bioaccumulation potential based on study results
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