Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 617-219-8 | CAS number: 81334-34-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Two Activated Sludge Respiration Inhibition studies with two read-across substances are available. Read-across with CAS 081335-37-7 revealed an EC50 >100 mg/L. In the study with the read-across substance CAS 114311-32-9, the EC50 was estimated to be >1000 mg/L
Key value for chemical safety assessment
Additional information
Read-across was applied using characteristically similar compounds: 2-[4,5-dihydro-4-methyl-4-(l-methylethyl)-5-oxo-lH-imadazol-2-yl]-5-(methoxymethyl)-3-pyridinecarboxylic acid (CAS 114311-32-9) and 2-[4,5-dihydro-4-methyl-4-(l-methylethyl)-5-oxo-lH-imidazol-2-yl]-3-quinolinecarboxylic acid (CAS 081335-37-7).
WoE (BASF, EXA 02 -001, 2002; EXA 01 -043, 2002)
Activated Sludge Respiration Inhibition studies, performed according to OECD guideline 209, with the read-across substances CAS 081335-37-7 and CAS 114311-32-9 are available. The study with CAS 081335-37-7 was performed with nominal test substance concentrations of 5, 10, 30, 60 and 100 mg/L. Respiration rate reduction was <50% in all test substance treatments. The EC50 value was estimated to be >100 mg/L, the highest concentration tested. In the Activated Sludge Respiration Inhibition study with CAS 114311-32-9, nominal concentrations of 100, 250, 500, 750 and 1000 mg/L were tested. Under the conditions of this test, an EC50 value >1000 mg/L was determined.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
