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Description of key information

Two Activated Sludge Respiration Inhibition studies with two read-across substances are available. Read-across with CAS 081335-37-7 revealed an EC50 >100 mg/L. In the study with the read-across substance CAS 114311-32-9, the EC50 was estimated to be >1000 mg/L

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Additional information

Read-across was applied using characteristically similar compounds: 2-[4,5-dihydro-4-methyl-4-(l-methylethyl)-5-oxo-lH-imadazol-2-yl]-5-(methoxymethyl)-3-pyridinecarboxylic acid (CAS 114311-32-9) and 2-[4,5-dihydro-4-methyl-4-(l-methylethyl)-5-oxo-lH-imidazol-2-yl]-3-quinolinecarboxylic acid (CAS 081335-37-7).

 

WoE (BASF, EXA 02 -001, 2002; EXA 01 -043, 2002)

Activated Sludge Respiration Inhibition studies, performed according to OECD guideline 209, with the read-across substances CAS 081335-37-7 and CAS 114311-32-9 are available. The study with CAS 081335-37-7 was performed with nominal test substance concentrations of 5, 10, 30, 60 and 100 mg/L. Respiration rate reduction was <50% in all test substance treatments. The EC50 value was estimated to be >100 mg/L, the highest concentration tested. In the Activated Sludge Respiration Inhibition study with CAS 114311-32-9, nominal concentrations of 100, 250, 500, 750 and 1000 mg/L were tested. Under the conditions of this test, an EC50 value >1000 mg/L was determined.