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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

Two Activated Sludge Respiration Inhibition studies with two read-across substances are available. Read-across with CAS 081335-37-7 revealed an EC50 >100 mg/L. In the study with the read-across substance CAS 114311-32-9, the EC50 was estimated to be >1000 mg/L

Key value for chemical safety assessment

Additional information

Read-across was applied using characteristically similar compounds: 2-[4,5-dihydro-4-methyl-4-(l-methylethyl)-5-oxo-lH-imadazol-2-yl]-5-(methoxymethyl)-3-pyridinecarboxylic acid (CAS 114311-32-9) and 2-[4,5-dihydro-4-methyl-4-(l-methylethyl)-5-oxo-lH-imidazol-2-yl]-3-quinolinecarboxylic acid (CAS 081335-37-7).


WoE (BASF, EXA 02 -001, 2002; EXA 01 -043, 2002)

Activated Sludge Respiration Inhibition studies, performed according to OECD guideline 209, with the read-across substances CAS 081335-37-7 and CAS 114311-32-9 are available. The study with CAS 081335-37-7 was performed with nominal test substance concentrations of 5, 10, 30, 60 and 100 mg/L. Respiration rate reduction was <50% in all test substance treatments. The EC50 value was estimated to be >100 mg/L, the highest concentration tested. In the Activated Sludge Respiration Inhibition study with CAS 114311-32-9, nominal concentrations of 100, 250, 500, 750 and 1000 mg/L were tested. Under the conditions of this test, an EC50 value >1000 mg/L was determined.