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EC number: 617-219-8 | CAS number: 81334-34-1
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- Ecotoxicological Summary
- Aquatic toxicity
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- Short-term toxicity to fish
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- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The toxic effects of the test substance was estimated in both, freshwater (Daphnia magna) and marine species (Penaeus duorarum, Crassostrea virginica). In all acute toxicity assays an EC50 value >100 mg/L was observed.
Key value for chemical safety assessment
Additional information
Weight of evidence
Freshwater species
WoE (American Cyanamid Company, 30098, 1983)
An acute toxicity study with Daphnia magna under static conditions
was performed equivalent to OECD guideline 202. Water fleas were exposed
to nominal test item concentrations of 10, 18, 32, 56 and 100 mg/L for a
period of 48 hours. No analytical verification of the nominal test
concentrations was performed. Under the conditions of this study, the
test item was determined to be practically non-toxic to daphnids with an
EC50 value >100 mg/L.
Marine species
WoE (American Cyanamid Company, 87384-0200-2130, 1988)
A flow-through saltwater toxicity test was conducted to determine
the acute toxicity of the test item to Pink shrimp (Penaeus duorarum).
The test organisms were exposed to nominal test item concentrations of
0, 26, 43, 72, 120 and 200 mg/L for a period of 96 hours. The
corresponding determined mean measured concentrations were <10.1, 25.0,
38.1, 60.6, 111 and 189 mg/L. The criterion for effect was death. After
96 hours of exposure an LC50 >189 mg/L was determined. One shrimp died
at the second highest concentration level (111 mg/L), but mortality did
not appear to be related to the treatment. No other signs of toxicity
were observed. Therefore, the NOAEC was determined to be 189 mg/L, the
highest concentration tested.
WoE (American Cyanamid Company,
87384-0400-2130, 1988; 954-97-139, 1997)
Two flow-through toxicity tests were conducted to determine the
acute effect of the test substance on the Eastern oyster (Crassostrea
virginica) after 96-hour of exposure. The criterion of effect was in
both tests reduced shell growth of exposed oysters compared to shell
growth of the control oysters. In the first study (American Cyanamid,
87384-0400-2130, 1988) Eastern oyster were exposed to nominal
concentrations of 0, 25.9, 43, 72, 120 and 200 mg test item/L for 96
hours. These concentrations correspond to the following mean measured
concentrations: <10.5, 21.5, 42.4, 65.5, 109 and 173 mg/L. After 96
hours of exposure an EC50 of >173 mg/L was determined. No mortalities
were observed in either the treated or control groups. There was a
statistically significant decrease in mean shell deposition at 173 mg/L
when compared to the control group (p ≤0.05). The NOAEC was determined
to be 109 mg/L based on measured concentrations.
In the second acute toxicity test (American Cyanamind, 954-97-139, 1997)
Eastern oyster were exposed to nominal test substance concentrations of
0, 16, 26, 43, 72 and 120 mg/L, which corresponds to the mean measured
concentrations of <LOQ, 16, 27, 46, 80 and 132 mg/L. Under the
conditions of this test, the 96-hour EC50 value for eastern oysters
exposed to the test substance was estimated as >132 mg/L, the highest
concentration tested. The NOEC was 132 mg/L. No significant adverse
effects were observed on shell deposition for any treated group.
Conclusion:
The test item was determined to be practically non-toxic to the
freshwater species, Daphnia magna and marine Pink shrimp and Eastern
oyster. In all acute toxicity assays an EC50 value >100 mg/L was
observed.
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