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Ecotoxicological information

Toxicity to birds

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Description of key information

21-day oral toxicity studies in Mallard ducks and Bobwhite quail revealed an LD50 >2150 mg/kg bw.

8-day dietary studies in Mallard ducks and Bobwhite quail revealed an LC50 >5000 mg/kg diet.

One-generation reproductive toxicity study in Mallard ducks and Bobwhite quail revealed an NOEC >2000 mg/kg diet.

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Weight of evidence:

Oral gavage studies (American Cyanamid Company, 716 -743 -4557, 716 -743 -4667, 1983)

Two 21-day oral gavage studies with the test substance in birds were conducted. Mallard ducks (Anas platyrhynchos) and Bobwhite quail (Colinus virginianus) were exposed to test substance concentrations of 1470 and 2150 mg/kg bw (in Corn oil) and a solvent control group. The test substance was determined to be practically non-toxic to Bobwhite quail and Mallard ducks with LD50 of >2150 mg/kg for both species.

Dietary studies (American Cyanamid Company, 715 -743 -4557, 1983)

Two 8-day dietary studies with the test substance in birds were conducted. Mallard ducks (Anas platyrhynchos) and Bobwhite quail (Colinus virginianus) were exposed to test substance concentrations of 312, 625, 1250 and 5000 mg/kg diet and a control group. The test substance was determined to be practically non-toxic to Bobwhite quail and Mallard ducks with LC50 of >5000 mg/kg diet for both species.

One generation study (Cyanamid Company, 715 -743 -4557, 1987)

Two one-generation studies with the test substance in birds were conducted. Mallard ducks (Anas platyrhynchos) and Bobwhite quail (Colinus virginianus) were exposed to test substance concentrations of 500, 1000 and 2000 mg/kg diet and a control group. In both studies, the test substance produced no evidence of treatment-related adverse effects on adult or reproductive parameters with an NOAEC of 2000 mg/kg diet.