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Environmental fate & pathways

Hydrolysis

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Description of key information

The test substance is stable to hydrolysis at environmental relevant pH values and temperatures.

Key value for chemical safety assessment

Half-life for hydrolysis:
325 d
at the temperature of:
25 °C

Additional information

Key study (American Cyanamid Company, PD-M 19-8, 1982)

A hydrolysis study was conducted to determine the rate of hydrolysis and degradation products of the test substance at a concentration of 50 ppm in pH 5.0, 7.0 and 9.0 buffer solutions and in distilled water at 25 °C. The test substance was stable in aqueous buffer solutions (pH 5 and 7) and distilled water (pH 5.2) for up to 30 days at 25 °C. Only 1.0% of the test substance had degraded in each of the pH 5.0 and pH 7.0 buffer solutions, and 1.4% in the distilled water solution. The test item degraded slowly in an aqueous pH 9 buffer solution. At this pH 7, three % of the test item had degraded at the end of 30 days and the half-life at pH 9.0 was calculated to be 325 days. The only identified degradation product was Nicotinic acid, 2-[(1-carbamoyl-1,2-dimethylpropyl)-carbamoyl]-.