Registration Dossier
Registration Dossier
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EC number: 617-219-8 | CAS number: 81334-34-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
In three acute bioassays with bluegills, trout and catfish a LC50 >100 mg/L was observed for the test substance.
Key value for chemical safety assessment
Additional information
Key study (American Cyanamid Company, 954-94-127, 1994)
The toxicity of the test substance to
Oncorhynchus mykiss (rainbow trout) was determined in a 96-hour acute
toxicity test under flow-through conditions equivalent to OECD guideline
203. Rainbow trout were exposed to nominal test item concentrations of
15.6, 25.9, 43.2, 72.0 and 120 mg/L, a formula blank and a negative
control (well water). These nominal concentrations corresponds to the
mean measured test item concentrations of 13, 29, 39, 68 and 110 mg/L.
Under the conditions of this test, the 96-hour LC50 value for the
rainbow trout exposed to the test item was > 100 mg/L, the highest
concentration tested. The 96-hour NOEC, determined by an examination of
mortality and clinical observation data, was 100 mg/L.
Supporting study (American Cyanamid Company, 30096, 1983)
Additionally, an acute toxicity test with Lepomis macrochirus (bluegill sunfish), performed equivalent to OECD guideline 203, is available. The bluegills were exposed to the nominal test item concentrations (in acetone) of 10, 18, 32, 53 and 100 mg/L for a period of 96 hours under static conditions. An analytical verification of the nominal test substance concentrations was not performed. As a quality check, the bluegill sunfish were challenged with a reference compound, Antimycin A. The estimated 96 hour LC50 and 95% confidence limits were within the 95% confidence limits reported in the literature, indicating that the fish were in good condition. The NOEC based on mortality and abnormal effects was 100 mg/L after 96 -hour. Therefore, the determined LC50 is >100 mg/L.
Supporting study (American Cyanamid Company, 300967 1983)
Additionally, an acute toxicity test with Ictalurus punctatus (channel catfish), performed equivalent to OECD guideline 203, is available. The catfish were exposed to the nominal test item concentrations (in acetone) of 10, 18, 32, 53 and 100 mg/L for a period of 96 hours under static conditions. An analytical verification of the nominal test substance concentrations was not performed. As a quality check, the catfish were challenged with a reference compound, Antimycin A. The estimated 96 hour LC50 and 95% confidence limits were within the 95% confidence limits reported in the literature, indicating that the fish were in good condition. The determined LC50 is >100 mg/L.
Conclusion:
Based on acute bioassays in three species, bluegills, trout and catfish the test substance is practically non-toxic to fish.
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