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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979

Materials and methods

Principles of method if other than guideline:
A dose of 500 mg/animal of chinizarin roh was applied to the inner surface of one ear each on 2 rabbits; exposure time was 24 hours. The test-substance was fixed by a plaster. After the exposition the test substance was removed with water and soap/plantoil. The post exposure observation time was 7 days.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
Chinizarin roh Pt. 229 II

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
not specified
Controls:
not required
Duration of treatment / exposure:
24 hours
Observation period:
7 days
Number of animals:
2 animals

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 0 h, 48 h, and 7 d
Score:
0
Max. score:
4
Reversibility:
other: not applicable - score = 0 at any time point
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 0 h, 48 h, and 7 d
Score:
0
Max. score:
4
Reversibility:
other: not applicable - score = 0 at any time point
Irritant / corrosive response data:
Chinizarin roh is not irritating to the skin (score = 0 at any time point).
Other effects:
No data.

Any other information on results incl. tables

No data.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Chinizarin roh is not irritating to the skin (score = 0 at any time point). According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is therefore not justified.
Executive summary:

A dose of 500 mg/animal of chinizarin roh was applied to the inner surface of one ear each on 2 rabbits; exposure time was 24 hours. The test-substance was fixed by a plaster. After the exposition the test substance was removed with water and soap/plantoil. The post exposure observation time was 7 days.

Chinizarin roh is not irritating to the skin (score = 0 at any time point).