Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report Date:
1979

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
One group of 10 male Wister rats (average weight 180-200 g) received a single cutaneous dose of 2500 mg/kg bw Chinizarin techn. tr.. The animals were observed for mortality and clinical signs through day 14.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: 50% lutrol
Duration of exposure:
24 hours
Doses:
2500 mg/kg bw
No. of animals per sex per dose:
10 male rats/dose
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
> 2 500 mg/kg bw
Based on:
test mat.
Mortality:
None of the animals died and no signs of intoxication were observed.
Clinical signs:
None of the animals died and no signs of intoxication were observed.
Body weight:
No data.
Gross pathology:
No data.
Other findings:
No data.

Any other information on results incl. tables

None of the animals died and no signs of intoxication were observed.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
None of the animals died and no signs of intoxication were observed. LD50 > 2500 mg/kg bw (rat, male). According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is therefore not justified.
Executive summary:

One group of 10 male Wister rats (average weight 180-200 g) received a single cutaneous dose of 2500 mg/kg bw Chinizarin techn. tr.. The animals were observed for mortality and clinical signs through day 14. None of the animals died and no signs of intoxication were observed. LD50 > 2500 mg/kg bw (rat, male).