Registration Dossier
Registration Dossier
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EC number: 201-368-7 | CAS number: 81-64-1
Endpoint summary
Administrative data
Description of key information
Several acute oral studies and a dermal toxicity study are available for 1,4-dihydroxyanthraquinone. No study is available for acute inhalation toxicity. This does not need to be conducted according REACH Annex VII column 2 because valid studies for acute oral and dermal toxicity are on hand.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- The materials/methods and results are described in detail and are sufficient for evaluation.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 500 mg/kg bw
- Quality of whole database:
- The materials/methods and results are described in detail and are sufficient for evaluation.
Additional information
In 3 valid acute oral toxicity studies a LD50 > 5000 mg/kg bw was found. None of the animals died at a single oral dose of 5000 mg/kg bw. In the acute dermal toxicity study the highest applied dose was 2500 mg/kg bw. None of the animals died after application of 2500 mg 1,4-dhihydroxyanthraquinone.
Justification for classification or non-classification
In 3 valid acute oral toxicity studies a LD50 > 5000 mg/kg bw was found. None of the animals died at a single oral dose of 5000 mg/kg bw. In the acute dermal toxicity study the highest applied dose was 2500 mg/kg bw. None of the animals died after application of 2500 mg 1,4-dhihydroxyanthraquinone.
According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is therefore not justified.
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