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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
specific investigations: other studies
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: special investigation

Data source

Reference
Reference Type:
publication
Title:
The influence of dihydroxyanthracene derivatives on water and electrolyte movement in rat colon
Author:
Lemmens L, Borja E
Year:
1976
Bibliographic source:
J Pharm Pharmac 28, 498-501 (1976)

Materials and methods

Principles of method if other than guideline:
The purgative activities of several dihydroxyanthracene derivatives were onvestigated by determining their influence on the water, sodium and potassium absorption in the gastrointestinal tract by direct injection of the solutions in Tyrode to the rat colon in situ.
GLP compliance:
no
Type of method:
in vitro
Endpoint addressed:
other: purgative activities of dihydroxyanthracene derivatives

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
other: in situ experiment
Vehicle:
other: tyrode
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
in situ experiment
Frequency of treatment:
in situ experiment
Post exposure period:
in situ experiment
Doses / concentrations
Remarks:
Doses / Concentrations:
2 ml of a 1mmol/l solution
Basis:
nominal conc.
No. of animals per sex per dose:
in situ experiment
Control animals:
no

Results and discussion

Details on results:
1,4-dihydroxyanthraquinone did not alter colonic water absorption but restricted sodium absorption and caused release of potassium into the lumen.

Applicant's summary and conclusion

Executive summary:

The purgative activities of several dihydroxyanthracene derivatives were onvestigated by determining their influence on the water, sodium and potassium absorption in the gastrointestinal tract by direct injection of the solutions in Tyrode to the rat colon in situ.

1,4-dihydroxyanthraquinone did not alter colonic water absorption but restricted sodium absorption and caused release of potassium into the lumen.