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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Principles of method if other than guideline:
50 mg test substance was applied into the conjuctival sac of 2 rabbits. Post exposure time was 7 days. Eyes were examinated after application of test substance up to 7 days
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-dihydroxyanthraquinone
EC Number:
201-368-7
EC Name:
1,4-dihydroxyanthraquinone
Cas Number:
81-64-1
Molecular formula:
C14H8O4
IUPAC Name:
1,4-dihydroxyanthraquinone
Test material form:
not specified
Details on test material:
Chinizarin roh Pt. 229 II

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
7 days
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
2 animals

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24, 48 and 72 h
Score:
0
Max. score:
4
Reversibility:
other: not applicable - score = 0 at any time point
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24, 48 and 72 h
Score:
0
Max. score:
2
Reversibility:
other:
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24, 48 and 72 h
Score:
0
Max. score:
3
Reversibility:
other:
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24, 48 and 72 h
Score:
0
Max. score:
4
Reversibility:
other:
Irritant / corrosive response data:
Chinizarin roh is not irritating to the eyes (cornea score, iris score, conjunctivae score and chemosis score = 0 at 24, 48 and 72 hours).
Other effects:
No data

Any other information on results incl. tables

No data.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Chinizarin roh is not irritating to the eyes (cornea score, iris score, conjunctivae score and chemosis score = 0 at 24, 48 and 72 hours). According to CLP classification criteria (Regulation (EC) No 1272/2008) a classification is therefore not justified.
Executive summary:

50 mg test substance was applied into the conjuctival sac of 2 rabbits. Post exposure time was 7 days. Eyes were examinated after application of test substance up to 7 days.

Chinizarin roh is not irritating to the eyes (cornea score, iris score, conjunctivae score and chemosis score = 0 at 24, 48 and 72 hours).