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Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24 December 2015 to 22 March 2016
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study under GLP, HPLC method is less suitable for the surface active substance
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
GLP compliance:
yes
Type of method:
HPLC estimation method
Media:
other: cyanopropyl stationary phase
Radiolabelling:
no
Test temperature:
30°C
Details on study design: HPLC method:
EQUIPMENT
- Apparatus: Alliance Separation Module 2695 (Waters, Milford, MA, USA)
- Detector: Refractive index detector 2414 (Waters)
- Column: Hypersil BDS-CN, 150 mm x 4.6 mm i.d., dp = 5 µm (Thermo Fisher Scientific, Waltham, MA, USA)
- Column temperature: 35°C ± 1°C
- Mobile phase: 40/60 (v/v) methanol/water
- Flow: 1 mL/min
- Injection volume: 10 µL
- RI detection
Sensitivity 4
Time constant 1 second
Temperature 30°C
- pH: 7
- Solutes for dissolving test and reference substances: methanol/water 40/60

DETERMINATION OF DEAD TIME: no data

REFERENCE SUBSTANCE: Acetanilide

REPETITIONS: 2 for tes substance, reference substance and blanks

EVALUATION: comparison with retention time referebce substance
Key result
Type:
Koc
Value:
< 18
Temp.:
30 °C
Key result
Type:
log Koc
Value:
< 1.26
Temp.:
30 °C
Details on results (HPLC method):
- Retention times of reference substances used for calibration: 2.415 and 2.420 min

Kocof the test item

Substance

tr,1
[min]

tr,2
[min]

mean tr
(n=2)

log Koc

Koc

Acetanilide

2.415

2.420

 

1.26

 

Test item

1.475

1.474

1.475

< 1.26

<18

 

Validity criteria fulfilled:
not specified
Conclusions:
The logKoc of the substance is <1.26
Executive summary:

Using the HPLC method the logKoc of the substance was determined to be <1.26.

Description of key information

Using the HPLC method the logKoc of the substance was determined to be <1.26.

Key value for chemical safety assessment

Koc at 20 °C:
18

Additional information

The log Koc calculation in the BASF study is not further taken into account, as a study on the actual test substance is available.

[LogKoc: 1.26]