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EC number: -
CAS number: -
Wistar rats (160-200g) were given a single i.p. dose of 384.7 μg sodium
acid-[14C]sulfonate (DBS) (2.26±0.15 mg/kg bw) in a 0.6%
physiological NaCl solution. Excretion of14C in feces and
urine was monitored for 10 days.Within
10 days after dosing, the animals excreted 94.5% of the dose applied,
84.7% in the first 24h. i.p. treatment resulted in a minor14C
elimination in the feces(35.0±4.6%)
on the first day of the experiment, whereas renally excreted
radioactivity amounted to 49.7±5.7%.
From days 2-10 of the excretion study, however, the percentage of
radioactive products in the feces wassignificantly
higher than in the urine.The
results of this experiment showed that, independent of the route of
administration, the daily excretion of radioactive products occurs
mainly in the feces with the exception of the first day of the i.p.
experiment, when the peak of14C elimination was in the urine.
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