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Physical & Chemical properties

Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24 December 2015 to 22 March 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Qualifier:
equivalent or similar to
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Qualifier:
equivalent or similar to
Guideline:
EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
Principles of method if other than guideline:
The Pow was calculated from the water solubility and the octanol solubility
GLP compliance:
yes
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water
Analytical method:
other: based on visual inspection of the octanol and water phase
Key result
Type:
log Pow
Partition coefficient:
>= 0.22
Temp.:
20 °C
Remarks on result:
other: no data on pH
Key result
Type:
Pow
Partition coefficient:
>= 1.67
Temp.:
20 °C
Remarks on result:
other: no data on pH
Details on results:
The resulting solutions were clear at 500, 760 and 1000 g/L were clear.
The calculation is based on the maximum observed solubility in water and octanol (600 and 1000 g/L respectively) in a worst case
Conclusions:
The logPow is ≥ 0.22
Executive summary:

In the shake flask method the octanol and water solubility of the substance were assessed separately. The logPow is based on a calculation using the water and octanol solubiliy. The logPow is ≥ 0.22.

Description of key information

The logPow is based on a calculation using the water and octanol solubility. The logPow is ≥ 0.22.

Key value for chemical safety assessment

Log Kow (Log Pow):
0.22
at the temperature of:
20 °C

Additional information