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Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24 December 2015 to 22 March 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
- Principles of method if other than guideline:
- The Pow was calculated from the water solubility and the octanol solubility
- GLP compliance:
- yes
- Type of method:
- estimation method (solubility ratio)
- Partition coefficient type:
- octanol-water
- Analytical method:
- other: based on visual inspection of the octanol and water phase
- Key result
- Type:
- log Pow
- Partition coefficient:
- >= 0.22
- Temp.:
- 20 °C
- Remarks on result:
- other: no data on pH
- Key result
- Type:
- Pow
- Partition coefficient:
- >= 1.67
- Temp.:
- 20 °C
- Remarks on result:
- other: no data on pH
- Details on results:
- The resulting solutions were clear at 500, 760 and 1000 g/L were clear.
The calculation is based on the maximum observed solubility in water and octanol (600 and 1000 g/L respectively) in a worst case - Conclusions:
- The logPow is ≥ 0.22
- Executive summary:
In the shake flask method the octanol and water solubility of the substance were assessed separately. The logPow is based on a calculation using the water and octanol solubiliy. The logPow is ≥ 0.22.
Reference
Description of key information
The logPow is based on a calculation using the water and octanol solubility. The logPow is ≥ 0.22.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.22
- at the temperature of:
- 20 °C
Additional information
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