Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient information to determine reliability

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
no author
Year:
2003
Bibliographic source:
Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown (2):41, 2003 Cited in NISC.com

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Duration of treatment / exposure:
30 days
Frequency of treatment:
"intermittent"

Results and discussion

Effect levels

Dose descriptor:
other: TDlo
Effect level:
1 575 mg/kg bw/day (nominal)
Sex:
not specified
Basis for effect level:
other: BLOOD - Other changes BIOCHEMICAL EFFECTS - Metabolism (intermediary) - Other proteins; Metabolism (intermediary)

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion