Registration Dossier
Registration Dossier
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EC number: 209-940-8 | CAS number: 598-56-1
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- publication
- Title:
- Preventing Vision Disturbances and Acute Physical Distress Due to Dimethylethylamine (DMEA) Exposure
- Author:
- NIOSH
- Year:
- 1 987
- Bibliographic source:
- DHHS (NIOSH) Publication No. 88-103 (http://www.cdc.gov/niosh/88-103.html)
Materials and methods
- Study type:
- health record from industry
- Endpoint addressed:
- eye irritation
- repeated dose toxicity: inhalation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- This Alert describes the effects of exposure to DMEA among workers in an aluminum casting foundry
Test material
- Reference substance name:
- Ethyldimethylamine
- EC Number:
- 209-940-8
- EC Name:
- Ethyldimethylamine
- Cas Number:
- 598-56-1
- Molecular formula:
- C4H11N
- IUPAC Name:
- ethyldimethylamine
Constituent 1
Method
- Type of population:
- occupational
Results and discussion
Applicant's summary and conclusion
- Executive summary:
This Alert describes the results of a National Institute for Occupational Safety and Health (NIOSH) investigation at an aluminum casting foundry where workers exposed to dimethylethylamine (DMEA) reported vision disturbances (blurred, foggy, and halo vision) and systemic effects (headache, nausea, and stomach pain) during coremaking operations. The vision disturbances and systemic effects occurred among workers exposed to DMEA at an 8-hour time-weighted average (TWA) concentration equal to or greater than 6 milligrams per cubic meter of air (6mg/m3, or 2 parts per million [ppm]). The adverse health effects may also have been caused by 15-minute DMEA exposures as high as 29 mg/m3(9.7 ppm). Acute physical distress and halo vision were experienced at concentrations higher than those associated with blurred vision only.
Excessive concentrations of DMEA resulted from a failure to maintain pressure-tight seals in the corebox machine gaskets. NIOSH recommends increased maintenance on these gaskets and more periodic checks of core machine operation to prevent excessive concentrations of DMEA in the workplace. Currently, no OSHA permissible exposure limit (PEL) exists for DMEA. Thus airborne concentrations of DMEA should be reduced so that vision disturbances and systemic effects do not occur.
Aluminum and gray-iron foundry owners, operators, and workers, manufacturers of polyamides, other users of DMEA, trade associations, labor organizations, and editors of appropriate trade journals are requested to help prevent exposure to DMEA.
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