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The nasal irritation produced by DMEA, TMA and TEA was studied using male Swiss OF1mice. Groups of six mice each were exposed to concentrationsof 84 -216, 17 -70 and 77 -305 ppm in air respectively for 15 min to determine the concentration at which the respiratory rate was decreased by 50% (RD50) (Gagnaire et al., 1989). The head of each mouse was isolated in an inhalation chamber, and the breathing frequency was measured with a pressure transducer before and during the exposure period. The RD50for DMEA, TMA and TEA were 161, 61 and 156 ppm, respectively and maximal effects were observed within 0.5 to 1 min.


The authors also exposed groups of mice to 251 to 610 ppm of DMEA via tracheal cannulation for 120 min. The concentration that caused a 50% decrease in respiratory rate via this route (RD50TC) was 691 ppm.