Registration Dossier

Administrative data

Key value for chemical safety assessment

Toxic effect type:
dose-dependent

Effects on fertility

Effect on fertility: via oral route
Endpoint conclusion:
no study available
Effect on fertility: via inhalation route
Endpoint conclusion:
no study available
Effect on fertility: via dermal route
Endpoint conclusion:
no study available

Effects on developmental toxicity

Effect on developmental toxicity: via oral route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via inhalation route
Endpoint conclusion:
no study available
Effect on developmental toxicity: via dermal route
Endpoint conclusion:
no study available

Toxicity to reproduction: other studies

Additional information

No repeated dose toxicity study is available on DMEA. However, a chronic inhalation toxicity study was performed with a structural analogue substance, tri-ethylamine:

Male and female F-344 rats were exposed at 0, 25, or 247 ppm triethylamine vapor, 6 h per day, 5 days per week for up to 28 weeks in order to characterize the sub-chronic organ system toxicity. Rats were weighed biweekly and scheduled sacrifices were performed following about 30, 60 and 120 days of exposure. No gross or histopathologic lesions attributable to TEA exposure were noted in any of the male and female reproductive organs examined.

Justification for classification or non-classification