Registration Dossier
Registration Dossier
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EC number: 252-276-9 | CAS number: 34893-92-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: sufficient documented and scientifically acceptable
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- a cotton swab soaked with 0.5 ml of compound was applied into the ear of 1-2 rabbits for 1, 8 or 24 h. Post-observation time was 7 days
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3-dichloro-5-isocyanatobenzene
- EC Number:
- 252-276-9
- EC Name:
- 1,3-dichloro-5-isocyanatobenzene
- Cas Number:
- 34893-92-0
- Molecular formula:
- C7H3Cl2NO
- IUPAC Name:
- 1,3-dichloro-5-isocyanatobenzene
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 1, 8, or 24 h
- Observation period:
- up to 7 days
- Number of animals:
- 1-2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h, 2, 5, 6, 7 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: exposure for 1 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h, 2, 5, 6, 7 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: exposure for 1 h
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h, 2, 5, 6, 7 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: exposure for 8 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h, 2, 5, 6, 7 d
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: exposure for 8 h
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h, 2, 5, 6, 7 d
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 7 d
- Remarks on result:
- other: exposure for 24 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 and 48 h
- Score:
- 1
- Max. score:
- 4
- Remarks on result:
- other: exposure for 24 h
- Other effects:
- no data
Any other information on results incl. tables
After the removal of the bandage there was no skin reaktion on 1 of the 2 animals treated for 1 hours and on both rabbits treated for 8 hours. The rabbit treated for 24 hours showed a strong erythema and up to 2 days a mildly edema.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
method: a cotton swab soaked with 0.5 ml of compound was applied into the ear of 1-2 rabbits for 1, 8 or 24 h. Post-observation time was 7 days
result: not irritating (application time: 1 or 8 h)
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