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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: sufficient documented and scientifically acceptable
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Principles of method if other than guideline:
100 µl of the liquefied test substance (at 30°C) was applied into the conjunctival sac of 2 rabbits. the post-observation time was 7 days
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-dichloro-5-isocyanatobenzene
EC Number:
252-276-9
EC Name:
1,3-dichloro-5-isocyanatobenzene
Cas Number:
34893-92-0
Molecular formula:
C7H3Cl2NO
IUPAC Name:
1,3-dichloro-5-isocyanatobenzene
Details on test material:
no data

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Duration of treatment / exposure:
see observation period
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
2

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 0, 24, 48 h, 5, 6, and 7 d
Score:
0
Max. score:
4
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 0, 24, 48 h, 5, 6, and 7 d
Score:
0
Max. score:
2
Irritation parameter:
other: erythema
Basis:
mean
Time point:
other: 0, 24, 48 h
Score:
1.7
Max. score:
4
Reversibility:
not fully reversible within: 7 d
Irritation parameter:
other: erythema
Basis:
mean
Time point:
other: 5, 6, 7 d
Score:
1
Max. score:
4
Reversibility:
not fully reversible within: 7 d
Irritation parameter:
other: edema
Basis:
mean
Time point:
other: 0, 24, 48 h
Score:
1
Max. score:
4
Irritation parameter:
other: edema
Basis:
animal #1
Time point:
other: 5, 6, 7 d
Score:
1
Max. score:
4
Irritation parameter:
other: edema
Basis:
animal #2
Time point:
other: 5, 6, 7 d
Score:
0
Max. score:
4

Any other information on results incl. tables

Up to 24 h a mildly reddening of the conjunctivae and an slightly edema was seen. Afterwards the conjunctivae of 1 animal was mildly reddened during the post-observation period. The other animal revealed form day 5 to 7 of the post-observation period a mildly reddening of the conjunctivae but no edema.

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information
Executive summary:

method: 100 µl of the liquedfied test substance (at 30°C) was applied into the conjunctival sac of 2 rabbits.

result: substance is slightly irritating. No adverse effects on cornea and iris were seen during the post-observation period in both animals.

During the post-observation time the erythema and edema scores of both amimals were below 2.

Therefore a classification is not justified.