Registration Dossier
Registration Dossier
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EC number: 252-276-9 | CAS number: 34893-92-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented and scientifically acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- 5 male and 5 female rats received 5 ml/kg bw (= 7000 mg/kg bw) of 3,5-Dichlorophenyl isocyanate per gavage. Post observation time 14 days
- GLP compliance:
- not specified
- Test type:
- other: single dosage (limit test)
Test material
- Reference substance name:
- 1,3-dichloro-5-isocyanatobenzene
- EC Number:
- 252-276-9
- EC Name:
- 1,3-dichloro-5-isocyanatobenzene
- Cas Number:
- 34893-92-0
- Molecular formula:
- C7H3Cl2NO
- IUPAC Name:
- 1,3-dichloro-5-isocyanatobenzene
- Details on test material:
- liquid compound
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5 ml/kg bw = 7000 mg/kg bw (density ca. 1.404 g/cm³)
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- post observation time: 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 7 000 mg/kg bw
- Mortality:
- with 5 ml/kg bw 1 animal died on day 1 and one animal died on day 2,
no symptoms and no influence on body weight with 3.1 ml/kg bw = 4350 mg/kg bw (density ca. 1.404 mg/cm³) - Clinical signs:
- other: sedation, reduction of general condition
- Gross pathology:
- no data
Any other information on results incl. tables
LD50 > 5 ml/kg bw (7000 mg/kg bw). density of 3,5-Dichlorophenyl isocyanate ca. 1404 mg/cm³
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information
- Executive summary:
5 male and 5 female rats received 5 ml/kg bw (= 7000 mg/kg bw) 3.5-dichlorophenyl isocyanate by gavage. One animal died on day 1 and one animal died on day2. No symptoms were seen with application of 3.1 ml/kg bw (= 4350 mg/kg bw). LD50 is > 5 ml/kg bw (= 7000 mg/kg bw).
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