Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: inhalatio hazard test

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Principles of method if other than guideline:
Test substance was liquefied at 30°C and evaporated. 200 l of air were conducted through 50 g of test substance and given 5 male and 5 female rats respectively for inhalation. Animals were housed in a 10 l chamber and trated for 10 or 30 min, 1, 3 or 7 hours.
GLP compliance:
not specified
Test type:
other: inhalation hazard test

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-dichloro-5-isocyanatobenzene
EC Number:
252-276-9
EC Name:
1,3-dichloro-5-isocyanatobenzene
Cas Number:
34893-92-0
Molecular formula:
C7H3Cl2NO
IUPAC Name:
1,3-dichloro-5-isocyanatobenzene
Details on test material:
lot no 2270

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
>= 10 - <= 420 min
Concentrations:
air saturated with test subsance
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
other: Lt50
Effect level:
>= 30 other: min
Exp. duration:
30 min
Remarks on result:
other: 50% of the animals died in a saturated test atmosphere with 3,5-dichlorphenyl isocyanate
Mortality:
50 % of the animals died between 30 min and 60 min in a atmosphere saturated with 3,5-dichlorophenyl isocyanate
Clinical signs:
other: abnormal behaviour, laboured breathing, reddening of eyes and nose, lacrimation
Body weight:
rats which were exposed only for 10 min showed normal weight gain. surviving animals of an exposure of 30 min or above showed a clear weight loss
Gross pathology:
reddish dicolored, edematous and inflated lungs, which were discolored dark reddish after 10 min and greyish or reddish after 30 min

Any other information on results incl. tables

clinical signs: abnormal behaviour, laboured breathing. during the first post-observation day the visible mucosa of eyes and nose were reddened and an elevated lacrimation was seen

pathology: dark red discoloured, edematous and inflated lungs.

Applicant's summary and conclusion

Interpretation of results:
very toxic
Remarks:
Migrated information
Executive summary:

Test substance was liquefied at 30°C and evaporated. 200 l of air were conducted through 50 g of test substance and given 5 male and 5 female rats respectively for inhalation. Animals were housed in a 10 l chamber and treated wholebody for 10 or 30 min, 1, 3 or 7 hours. 50 % of the animals died after an exposure time between 30 and 60 minutes