Registration Dossier
Registration Dossier
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EC number: 931-313-9 | CAS number: -
Specific investigations: other studies
Administrative data
- Endpoint:
- nephrotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (public available peer reviewed source). The original source is available and has been reviewed.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Effect of dichlorobutenes on the function and structure of the kidneys.
- Author:
- Petrosyan FR, Gizhlaryan MS, Khechumov SA, Ervanyan AK, Darbinyan NA, Kavkasyan GV
- Year:
- 1 983
- Bibliographic source:
- Zh. Eksp. Klin. Med. 23, 417-421.
- Reference Type:
- secondary source
- Title:
- 1,4-Dichlorobut-2-ene - CAS No: 764-41-0
- Author:
- OECD SIDS
- Year:
- 2 006
- Bibliographic source:
- SIDS Initial Assessment Report for 22th SIAM, UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
- Type of method:
- in vivo
Test material
- Reference substance name:
- 1,4-dichlorobut-2-ene
- EC Number:
- 212-121-8
- EC Name:
- 1,4-dichlorobut-2-ene
- Cas Number:
- 764-41-0
- Molecular formula:
- C4H6Cl2
- IUPAC Name:
- 1,4-dichlorobut-2-ene
- Details on test material:
- - Name of test material (as cited in study report): 1,4-dichlorobut-2-ene
- Analytical purity:no data
Constituent 1
Test animals
- Species:
- rat
Results and discussion
- Details on results:
- Single administration of 1,4-dichlorobut-2-ene to rats caused specific nephrotoxic changes manifested by disruption of canalicular reabsorption and development of necrotic nephrosis. Urinary creatinine excretion increased, compared to the control, by 65-77% after 1,4-dichlorobenzene administration. Chlorides in the urine decreased substantially (54-73%, 1,4-dichlorobenzene). Serum creatinine, however, was unchanged. Chronic intoxication affected the filtration function of the kidney and caused dystrophic changes in canalicular epithelium and glomeruli.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
