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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Adopted according to OECD SIDS (public available peer reviewed source). The original source is available and has been reviewed.
Cross-reference
Reason / purpose:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-finding toxicity data: List IV
Author:
Smyth Jr. HF, Carpenter CP, Weil CS
Year:
1951
Bibliographic source:
Arch. Ind. Hyg. Occup. Med. 4, 119-122.
Reference Type:
secondary source
Title:
1,4-Dichlorobut-2-ene- CAS No: 764-41-0
Author:
OECD SIDS
Year:
2006
Bibliographic source:
SIDS Initial Assessment Report for 22th SIAM, UNEP Publications

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Dermal LD50 has been determined with rabbits, after 24-hour dermal exposure under occlusive conditions. Method described in: Smyth et al., J. Ind. Hyg. Toxicol. 30, 63-68 (1948).
GLP compliance:
no
Remarks:
GLP was not mandatory at the time of the study.
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 1,4-dichlorobut-2-ene.
- Analytical purity: no data.

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Duration of exposure:
24 hours
Doses:
no data
No. of animals per sex per dose:
6 per dose group (sex of the animals not reported)
Details on study design:
- Duration of observation period following administration: 14 days.
Statistics:
Standard deviations calculated by the method of Thompson (1947)

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
735 mg/kg bw
Based on:
test mat.
95% CL:
557 - 960

Applicant's summary and conclusion