Registration Dossier

Ecotoxicological information

Toxicity to soil macroorganisms except arthropods

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

LC50 (14 d) > 1000 mg/kg dw for Eisenia fetida (OECD 207/EU Method C.8)

Key value for chemical safety assessment

Additional information

Since no studies investigating the toxicity to soil macroorganism of Propyleneglycol dioleate (CAS 105-62-4) are available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across was conducted to the two structurally related substances butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) and decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7). This read-across is justified in detail in the overall summary (IUCLID chapter 6.3) and within the analogue justification in IUCLID Section 13.

The study with butylene glycol dicarprylate/dicaprate was performed according to OECD 207 under GLP conditions (Lührs, 2001). Eisenia fetida was exposed to 5 different test substance concentrations up to 1000 mg/kg dw in artificial soil for 14 d. Mortality and body weight were recorded at the end of the study. No mortality was observed resulting in a LC50 of > 1000 mg/kg dw. The body weight increased significantly at a test concentration of 1000 mg/kg dw. Therefore, a NOEC of 500 mg/kg dw was determined.

Eisenia foetida foetida was used in the second study according to EU Method C.8 (GLP) to evaluate the toxicity of decanoic acid, mixed diesters with octanoic acid and propylene glycol to soil macroorganisms (Scholz, 1996). A limit test with a concentration of 1000 mg/kg dw did not result in mortality after 14 d of exposure. Therefore, a LC50 > 1000 mg/kg dw was determined.

Based on the results from structurally related read-across substances (in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5) which are characterized by an equal ecotoxicological profile, it can be concluded that Propyleneglycol dioleate (CAS 105-62-4) will not exhibit toxic effects to soil macroorganisms.