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Long-term toxicity to aquatic invertebrates

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Description of key information

No chronic effects to aquatic invertebrates up to the limit of water solubility.

Key value for chemical safety assessment

Additional information

Since no studies investigating the long-term toxicity to aquatic invertebrates of Propyleneglycol dioleate (CAS 105-62-4) are available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across to another structurally related substance butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) was conducted. This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the analogue justification in IUCLID Section 13.

The study was performed according to the OECD Guideline 211 under GLP conditions (Hertl, 2001). Daphnia magna was exposed to individually prepared Water Accommodated Fractions (WAF’s) of nominal 6.25, 12.5, 25, 50 and 100 mg/L under semi-static conditions. Analytical determination of test solution concentration resulted in very low concentrations of 0.03 mg/L in freshly prepared medium and concentrations below the detection limit of 0.01 mg/L before test medium renewal periods after every 48 or 72 h, respectively. After 21 d, no particular signs of intoxication, no mortality and no effects on the mean reproduction rate were observed throughout the test resulting in an EL50 of > 0.02 mg/L (measured, arithm. mean) and a NOELR of ≥ 0.02 mg/L (measured, arithm. mean).

Based on the results from a structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile, it can be concluded that Propyleneglycol dioleate (CAS 105-62-4) will not exhibit chronic effects to aquatic invertebrates up to the limit of water solubility.