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Long-term toxicity to fish

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Description of key information

The chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 does not indicate the need to investigate further the long-term toxicity to fish.

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Additional information

No experimental data on long-term toxicity to fish are available for Propyleneglycol dioleate (CAS 105-62-4).The chemical safety assessment according to Annex I of Regulation (EC) 1907/2006 does not indicate the need to investigate further the long-term toxicity to fish.

No effects were observed in a chronic study with Daphnia magna according to OECD 211 (NOELR ≥ 0.02 mg/L) with the read-across substance butylene glycol dicaprylate / dicaprate (CAS 853947-59-8). Moreover, no effects were observed with structurally related substances in short-term studies with fish and aquatic invertebrates. As there was no sign that invertebrates are less sensitive than fish in the short term tests, it can not be expected that a long-term test with fish will generate different results than the existing long-term test with invertebrates. Furthermore, it is not likely that aquatic organisms are exposed to the test substance since it will be ultimately degraded in sewage treatment plants, due to its ready biodegradability.

Thus, based on the above mentioned results, it can be concluded that Propyleneglycol dioleate does not show any chronic toxicity to fish up to the limit of water solubility. Hence due to animal welfare reasons and to avoid unnecessary vertebrate tests, no further long-term test with fish is required for Propyleneglycol dioleate.