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Toxicity to aquatic algae and cyanobacteria

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Description of key information

No toxic effects to aquatic algae up to the limit of water solubility.

Key value for chemical safety assessment

Additional information

Since no studies investigating the toxicity to aquatic algae and cyanobacteria of Propyleneglycol dioleate (CAS 105-62-4) are available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across conducted to the two structurally related substances butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) and decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7). This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the analogue justification in IUCLID Section 13.

The study with butylene glycol dicaprylate / dicaprate was performed as a limit test according to EU Method C.3 using the freshwater algae Scenedesmus subspicatus (Scholz, 1997). A test substance concentration of 1000 mg/L (nominal) and 3 mg/L (measured, based on TOC content) respectively, did not result in any effects on the growth rate and biomass after 72 h resulting in an EL10/50 > 3 mg/L (measured, initial). The recovery rate in the stability test was > 80% and the concentration after 48 and 72 h did not differ more than 20%. Therefore, the test substance was bioavailable throughout the test.

The second study with the read-across substance decanoic acid, mixed diesters with octanoic acid and propylene was performed according to the EU Method C.3 under GLP conditions (Scholz, 1995). The green algae Scenedesmus subspicatus was exposed to a Water Accommodated Fraction (WAF) of nominal 5.3 mg/L and subsequent dilutions for 72 h. No effects on the growth rate of S. subspicatus up to the limit of water solubility were observed resulting in an ELr50 > 5.3 mg/L and a NOELR of ≥ 5.3 mg/L.

Based on the results from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile, it can be concluded thatPropyleneglycol dioleate (CAS 105-62-4)will not exhibit toxic effects to aquatic algae up to the limit of water solubility.