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Short-term toxicity to aquatic invertebrates

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Description of key information

No toxic effects to aquatic invertebrates up to the limit of water solubility.

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Additional information

Since no studies investigating the short-term toxicity to aquatic invertebrates of Propyleneglycol dioleate (CAS 105-62-4) are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across conducted to the two structurally related substances decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7) and butylene glycol dicaprylate / dicaprate (CAS 853947-59-8). This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the analogue justification in IUCLID Section 13.

The study with decanoic acid, mixed diesters with octanoic acid and propylene glycol was performed according to the EU Method C.2 under GLP conditions (Scholz, 1995). Daphnia magna was exposed to a measured concentration (geometric mean) of 2.4 mg/L in a static limit test for 48 h. Since the test solution was prepared by adding 1 g/L with subsequent filtration (WAF), the measured concentration of 2.4 mg/L represents the highest concentration which is soluble in water. No effects were observed resulting in an EL50 of > 2.4 mg/L.

The second study using butylene glycol dicaprylate / dicaprate supports this result (Scholz, 1997). It was conducted under the same conditions like the first study. Daphnia magna was exposed to a measured concentration (initial) of 2 mg/L in a static limit test for 48 h. The test concentration of 2 mg/L represents the highest soluble concentration, since 1 g/L was added to the test medium, stirred and subsequently filtered (WAF). No effects were observed, resulting in an EL50 of > 2 mg/L.

Based on the results from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile, it can be concluded that Propyleneglycol dioleate (CAS 105-62-4) will not exhibit acute toxic effects to aquatic invertebrates up to the limit of water solubility.