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Ecotoxicological information

Toxicity to microorganisms

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Description of key information

EC10 (16 h) > 10000 mg/L (ISO 10712, Pseudomonas putida)
EC10 (3 h) > 1099 mg/L (EU Method C.11, activated sludge)

Key value for chemical safety assessment

Additional information

Since no studies investigating the toxicity to microorganisms of Propyleneglycol dioleate (CAS 105-62-4) are available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across conducted to the two structurally related substances propylene glycol diisostearate (CAS 68958-54-3) and butylene glycol dicaprylate / dicaprate (CAS 853947-59-8). This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the analogue justification in IUCLID Section 13.

The study with propylene glycol diisostearate was performed according to ISO 10712 under GLP conditions with Pseudomonas putida (Mead, 1997). A filtered test substance concentration of nominal 10000 mg/L was tested in this study. No inhibition of growth was observed after an incubation of 16 h resulting in an EC10 of > 10000 mg/L (nominal). The influence of the read-across substance butylene glycol dicaprylate / dicaprate to activated sludge microorganisms was investigated in a GLP study according to EU Method C.11 (Diefenbach, 1997). A test concentration of nominal 1099 mg/L did not result in an inhibition of the respiration rate after 3 hours. Thus, an EC10 of > 1099 mg/L was derived.

Based on the results from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by an equal ecotoxicological profile, it can be concluded that Propyleneglycol dioleate (CAS 105-62-4) will not exhibit toxic effects to microorganisms.