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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

No toxic effects to fish up to the limit of water solubility.

Key value for chemical safety assessment

Additional information

Since no studies investigating the short-term toxicity to fish of Propyleneglycol dioleate (CAS 105-62-4) are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across was conducted to the two structurally related substances decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7) and propylene glycol diisostearate (CAS 68958-54-3). This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the analogue justification in IUCLID Section 13.

The study with the read-across substance decanoic acid, mixed diesters with octanoic acid and propylene glycol was performed as a limit test according to the EU Method C.1 (GLP) with the zebrafish Brachydanio rerio under semi-static conditions (Scholz, 1995). A Water Accommodated Fraction (WAF) of 1000 mg/L did not result in any effects although oily drops were visible after 72 and 96 h. The analytical determination of the test substance based on TOC-analysis resulted in very different values since they were oversaturated, whereas the effect concentration was based on the nominal values. Thus, a LL50 of > 1000 mg/L was determined.

The second study with the read-across substance propylene glycol diisostearate was performed according to OECD 203 under GLP conditions with the zebrafish Danio rerio (van Egmond, 1997). Five concentrations up to 100 mg/L were tested in a semi-static exposure regime. No effects were observed after an exposure of 96 h resulting in a LC50 > 100 mg/L. Based on the results from structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile, it can be concluded that Propyleneglycol dioleate (CAS 105-62-4) will not exhibit acute effects to fish up to the limit of water solubility.