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Diss Factsheets
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EC number: 292-588-2 | CAS number: 90640-67-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://www.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- purity not reported
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Amines, polyethylenepoly-, triethylenetetramine fraction
- EC Number:
- 292-588-2
- EC Name:
- Amines, polyethylenepoly-, triethylenetetramine fraction
- Cas Number:
- 90640-67-8
- Molecular formula:
- C6H18N4, C8H20N4
- IUPAC Name:
- Amines, polyethylenepoly-, triethylenetetramine fraction
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazleton Research Products, Denver PA
- Age at study initiation: young adults
- Weight at study initiation: 1.943-2.800 kg
- Fasting period before study: No
- Housing:individually in cages sized in accordance with the "Guide for the Care and Use of Laboratory Animals" of the Institute of Laboratory Animal Resources, National Research Council.
- Diet (e.g. ad libitum): Purina Lab Rabbit Chow H.F.
- Water (e.g. ad libitum): fresh tap water, ad libitum
- Acclimation period: min. 5d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C±3
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12h dark/12h light
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal area of trunk (clipped free of fur)
- Type of wrap if used: rubber dam and an elastic bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiped with water and gauze
- Time after start of exposure: 24h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1000, 2000 and 3000 mg/kg bw
- Constant volume or concentration used: yes - Duration of exposure:
- 24h
- Doses:
- 1000, 2000 and 3000 mg/kg bw
- No. of animals per sex per dose:
- 10 ( 5♂and 5♀)
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily through 14 days; body weight: d0,d7 and d14 or when dead
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, dermal observations - Statistics:
- By the method of Litchfield and Wilcoxon via the Innovative Programming Associates, LABCAT Module Version 4.24.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 465.4 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 074.6 - <= 1 998.3
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 720 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 082.9 - <= 2 732
- Mortality:
- -2/10 animals died at the 1000 mg/kg bw dose level
-8/10 animals died at the 2000 mg/kg bw dose level
-9/10 animals died at the 3000 mg/kg bw dose level - Clinical signs:
- other: - DECREASED ACTIVITY: 2/10 animals at 1000 mg/kg bw dose level; 7/10 animals at 2000 mg/kg bw dose level; 6/10 animals at 3000 mg/kg bw dose level; -ABNORMAL GAIT: 1/10 animals at 1000 & 3000 mg/kg bw dose level; 6/10 animals at 2000 mg/kg bw dose level
- Gross pathology:
- Necropsy of the animals that died on study revealed discolored and/or fluid-filled stomach, distended and/or fluid-filled intestines, discolored kidneys and liver, fluid-filled bladder and necrosis of the skin at the application site.
Terminal necropsy revealed discolored lungs in one animal and necrosis of the skin at the application site in all of the animals. No other visible lesions were observed in any animal at terminal necropsy .
Any other information on results incl. tables
The data generated for the acute dermal LD50 in females did not lend itself to the statistical method applied
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS Category 4 (H312) according to Regulation (EC) No 1272/2008
- Conclusions:
- Based on the observations made in the Acute Exposure Dermal Toxicity Study in rabbits, the acute dermal LD50 in males and combined sexes for 6933-6-20 was determined to be 1720.0 (1082.9-2732.0) mg/kg and 1465.4 (1074.6-1998.3) mg/kg, respectively. The data generated for the acute dermal LD50 in females did not lend itself to the statistical method employed.
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