Registration Dossier

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: exposure measurements

Data source

Reference
Reference Type:
publication
Title:
Exposure to low molecular polyamines during road paving
Author:
Levin, J.O., Andersson, K., Hallgren, C.
Year:
1994
Bibliographic source:
Ann occup. Hyg., Vol. 38, No 3. pp. 257 264.

Materials and methods

Type of study / information:
Measurement of TETA in the air during road pavement.
Endpoint addressed:
other: occupational exposure
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Method

Exposure assessment:
measured
Details on exposure:
TETA was found as aerosol

Results and discussion

Results:
TETA was measured in concentrations of 0.02 to 0.05 mg/m³.

Applicant's summary and conclusion

Executive summary:

Fatty amine wetting agents are used to increase adhesion in bitumen emulsions used in road paving, but commercial fatty amine products are contaminated with low molecular polyamines and alkanol polyamines which are released from the hot bitumen during paving. Polyamines and alkanol polyamines are known to cause eye and respiratory tract irritation and skin sensitization. The exposure of road pavers to ethylenediamine, diethylenetriamine, triethylenetetramine, tetraethylenepentamine, hydroxyethylethylenediamine, hydroxyethyldiethylenetriamine, monoethanolamine and diethanolamine was studied, since most of these compounds were found in the products used. Personal and static air sampling was performed during road paving. A highly sensitive measurement technique utilizing naphthylisothiocyanate-coated sorbents and filters was used. Exposure was found to be in the range <0.02-0.5 mg/m3, as total concentration of low molecular polyamines and alkanol polyamines. Since the polyamines and alkanol polyamines in question are highly irritating they may contribute to the symptoms experienced by the road pavers.