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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
1951
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies
Remarks:
The study was performed pre-GLP and pre-guideline. Limited reporting. No information on the composition or purity of the test substance.
Cross-referenceopen allclose all
Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1951
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The study was performed pre-GLP and pre-guideline. Limited reporting. No information on the composition or purity of the test substance.
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
no guideline available
Principles of method if other than guideline:
Range finding Toxicity study with the registration substance in rats. Oral application 10% aqueous solutions.
GLP compliance:
no
Remarks:
pre-GLP
Test type:
standard acute method
Limit test:
no
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: gavage
Vehicle:
water
Doses:
0.3, 1.0, 2.0, 3.0 g/kg bw
No. of animals per sex per dose:
3 and 2 in the low dose sex unknown
Control animals:
no
Sex:
not specified
Dose descriptor:
LD50
Effect level:
>= 1 000 - <= 2 000 mg/kg bw
Based on:
test mat.

Dose (g/kg bw)

No. Died/No. Fed

Remarks

3.0

3/3

Died in 1 day

2.0

2/3

 

1.0

1/3

 

0.3

0/2

No effects observed

Interpretation of results:
other: CLP/EU GHS Category 4 (H302) according to Regulation (EC) No 1272/2008
Conclusions:
The LD50 is between 1000 -2000 mg/kg bw based on the results of this study.
Executive summary:

An acute oral toxicity study was performed pre-guideline and pre-GLP with rats of unknown sex. 10% of the test substance in water was administered to the rats in doses of 3.0, 2.0, 1.0 and 0.3 g/kg bw. The LD50 is between 1000 -2000 mg/kg bw based on the results of this study.

Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
1951
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The study was performed pre-GLP and pre-guideline. Limited reporting. No information on the composition or purity of the test substance.
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
no guideline available
Principles of method if other than guideline:
Inhalation was via saturated atmosphere. Three rats per group were tested. In one group the bath temperature was 25°C and the animals were exposed for 8.0 hours. In the second group the bath temperature was 100°C and the animals were exposed for 7.0 hours.
GLP compliance:
no
Remarks:
pre-GLP
Test type:
other: no data
Limit test:
no
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
no
Concentrations:
No data
No. of animals per sex per dose:
3 rats of unknown sex per group
Control animals:
no
Dose descriptor:
LC50
Remarks on result:
not determinable because of methodological limitations
Mortality:
No deaths were observed.
Clinical signs:
other: No other effects were observed.
Other findings:
A strong ammoniacal odor was noticed at 100°C.
Interpretation of results:
study cannot be used for classification
Conclusions:
Acute exposure to the substance vapour for 8 hours (generated at a bath temperature of 25°C) or to substance fume for 7 hours (generated at a bath temperature of 100°C) did not induce toxic effects. No hazard is anticipated from the infrequent inhalation of substantially saturated vapour or fume at room temperature. The results of such a study, however, are not sufficient for classification for acute inhalation toxicity.
Executive summary:

Two groups of 3 rats each (of unknown sex) were exposed to the substance vapour or fume at room temperature. Inhalation was via saturated atmosphere. For one group the bath temperature was 25°C and the animals were exposed for 8.0 hours. For the second group the bath temperature was 100°C and the animals were exposed for 7.0 hours. No deaths were observed and no other effects. A strong ammoniacal odor was noticed.

Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
1951
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
no guideline available
GLP compliance:
no
Remarks:
pre-GLP
Species:
rabbit
Strain:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Duration of treatment / exposure:
No data
Observation period (in vivo):
No data
Number of animals or in vitro replicates:
No data

Material

Treatment

Response-remarks

100%

Unwashed

Marked to severe pain, irritation, and permanent corneal damage

100%

Washed H2O

Moderate pain, irritation, and very slight residual corneal damage

10% in water

Unwashed and washed H2O

Very slight to slight pain, irritation and transient corneal injury

1% in water

Unwashed and washed H2O

Very slight initial pain

Interpretation of results:
study cannot be used for classification
Conclusions:
Because necrosis was seen following treatment with the undiluted test substance, classification in Cat. 1 is assumed. Because of unknown exposure duration and unkown observation period etc., a definite classification is not possible.
Executive summary:

The eyes of rabbits were exposed to the test substance undiluted, and at 10% and 1% in water with and without washing the eyes. No further details on the methods. The undiluted test substance is corrosive to the eye and at 1% slight irritation is observed.

Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
1951
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
no guideline available
GLP compliance:
no
Remarks:
pre-GLP
Species:
rabbit
Strain:
not specified
Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
no
Duration of treatment / exposure:
1-12 minutes
Observation period:
No data
Number of animals:
No data

Material

Condition of the skin

Number of applications

Site

Response-remarks

100%

Intact

1 for 12 minutes

Belly

Severe hyperemia and slight denaturation

100%

Intact

1 for 6 minutes

Belly

Moderate hyperemia and slight denaturation

100%

Intact

1 for 3 minutes

Belly

Slight hyperemia

100%

Intact

1 for 1 minutes

Belly

No apparent effect

10% in H2O

Intact

10

Ear

Slight hyperemia

10% in H2O

Intact

4

Belly

Severe hyperemia, denaturation and slight edema

1% in H2O

Intact

10

Ear

No apparent effect

1% in H2O

Intact

10

Belly

Slight hyperemia

Interpretation of results:
study cannot be used for classification
Conclusions:
Because of the signs seen after 6 minutes, necrosis following treatment with the undiluted test substance, classification in Cat. 1 could be assumed. Because of unknown exposure duration and unkown observation period, classification in subcategories (1A, 1B, 1C) is not possible.
Executive summary:

The intact skin of belly or ears of rabbits were exposed to the test substance as undiluted, 10% and 1% in water. No further details on the methods. After 6 minutes exposure necrosis is seen.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1953
Report date:
1953

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Amines, polyethylenepoly-, triethylenetetramine fraction
EC Number:
292-588-2
EC Name:
Amines, polyethylenepoly-, triethylenetetramine fraction
Cas Number:
90640-67-8
Molecular formula:
C6H18N4, C8H20N4
IUPAC Name:
Amines, polyethylenepoly-, triethylenetetramine fraction
Test material form:
liquid
Radiolabelling:
no

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
no data
No. of animals per group:
no data

Results and discussion

Conversion factor human vs. animal skin:
no data

Any other information on results incl. tables

The material was not absorbed in acutely toxic amounts.

Applicant's summary and conclusion

Conclusions:
The material was not absorbed in acutely toxic amounts.
Executive summary:

Through rabbit skin the material was not absorbed in acutely toxic amounts. No further information.