Registration Dossier
Registration Dossier
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EC number: 231-639-5 | CAS number: 7664-93-9
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published non-standard study
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of sulfuric acid aerosols on pulmonary functions of guinea pigs
- Author:
- Silbaugh et al
- Year:
- 1 981
- Bibliographic source:
- J. Toxicol. Environ. Health, 7, 339-352
Materials and methods
- Type of study / information:
- Airway response in exposed guinea pigs
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Invetigation of airway response in guinea pigs exposed to sulphuric acid by inhalation
- GLP compliance:
- no
- Remarks:
- older published study
Test material
- Reference substance name:
- Sulphuric acid
- EC Number:
- 231-639-5
- EC Name:
- Sulphuric acid
- Cas Number:
- 7664-93-9
- Molecular formula:
- H2O4S
- IUPAC Name:
- sulfuric acid
Constituent 1
Results and discussion
Any other information on results incl. tables
Eight exposed animals exhibited increased total pulmonary resistance and decreased dynamic compliance. Four of these 8 responsive animals died during exposure. All other H2SO4-exposed animals exhibited no major differences from controls and were termed nonresponsive. The proportion of responsive to non-responsive animals increased with exposure concentration but the magnitude of pulmonary function change was similar for all responsive animals regardless of concentration. Compared to nonresponders, responsive animals had higher preexposure values of tidal transpulmonary pressure excursions and total pulmonary resistance and lower values of dynamic compliance. Preexposure transpulmonary pressure excursions were positively correlated with minute volume only for nonresponsive animals; transpulmonary pressure excursions were positively correlated with total pulmonary resistance in responsive animals.
Applicant's summary and conclusion
- Executive summary:
Exposure of guinea pigs to sulphuric acid aerosols by inhalation revealed an all-or-none response, with increased resistance and reduced compliance seen in a proportion of animals. It is postulated by the authors that sensitivity may be linked to pre-exposure.
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