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EC number: 231-639-5 | CAS number: 7664-93-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published investigative non-guideline, non-GLP study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Clearance Of Sulfuric Acid-Introduced 35S From The Respiratory Tracts Of Rats, Guinea Pigs And Dogs Following Inhalation Or Instillation
- Author:
- Dahl AR, Felicetti SA & Muggenburg BA
- Year:
- 1 983
- Bibliographic source:
- Fundamental & Applied Toxicology 3 (4) 293-297
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- The study was performed to elucidate the toxicokinetics of the sulphate anion following the inhalation exposure of various species to aerosols of sulphuric acid.
- GLP compliance:
- no
- Remarks:
- : older, published study
Test material
- Reference substance name:
- Sulphuric acid
- EC Number:
- 231-639-5
- EC Name:
- Sulphuric acid
- Cas Number:
- 7664-93-9
- Molecular formula:
- H2O4S
- IUPAC Name:
- sulfuric acid
- Details on test material:
- 35-S radiolabelled sulphuric acid
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 35S-sulphuric acid
Test animals
- Species:
- other: Rat, guinea pig and dog
- Strain:
- other: F344, Hartley, beagle
- Sex:
- male
Administration / exposure
- Route of administration:
- other: inhalation and instillation
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- See below for methodological details
Doses / concentrations
- Remarks:
- Doses / Concentrations:
See below for methodological details
- No. of animals per sex per dose / concentration:
- See below for methodological details
- Control animals:
- no
Results and discussion
- Preliminary studies:
- No information.
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- Clearance into the blood and gastrointestinal tract was measured along with determination of 35S remaining at the site of administration at sacrifice. Different rates of clearance from different sites within the dog lung were indicated with rates of clearance increasing with decreasing airway diameter. Half-times of clearance from all sites in the lung and for all species were from 2–9 min. There appeared to be some species differences, with clearance for dogs being slower than for guinea pigs, which was slower than for rats. Upper respiratory tract clearance was much slower than for lung and may not have been primarily by way of the blood.
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- Not applicable. The study was performed to elucidate the fate of the sulphate anion.
Any other information on results incl. tables
A considerable variability in clearance rates from blood and lungs was noted in rats and dogs. The half-time for 50% clearance from the lungs of all animals was in the range of 2-9 minutes. The rate of clearance for dogs was slower than guinea-pigs, which was slower than for rats. The clearance rates from the upper respiratory tract, trachea, and larynx were much slower than for lung for all three species of animals. The authors conclude that the half time for the clearance of sulphuric-acid in dogs, guinea-pigs, and rats is shorter than values reported in the literature involving isolated perfused lungs; smaller lung airways may clear faster than larger airways.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Sulphate is rapidly absorbed from the lungs following inhalation exposure to sulphuric acid. - Executive summary:
The clearance of 35S-radiolabeled sulphuric acid aerosols from the respiratory tract was studied in rats, guinea pigs, and dogs exposed nose-only to l-20 mg/m³ (MMAD 0.4-l .2 µm) for 30 seconds, and in rats and guinea pigs following intranasal installation (Dahl et al. 1983). The results indicated that the sulphur from sulphuric acid is rapidly cleared from the lungs into the blood following inhalation exposure. The lung clearance half-times were 170,230, and 261 seconds in rats, guinea pigs, and dogs, respectively. Very little sulphate from the sulphuric acid placed in the nose was absorbed into the rest of the body. Five minutes after treatment, 97.1% and 96.8% of the dose remained in the nose of rats and guinea pigs, respectively. To further study absorption of sulphuric acid by the respiratory tract of dogs, 35S-labeled sulphuric acid was instilled in one dog l-2 cm past the nares, in a second generation bronchus of another dog, and in a seventh generation bronchus of a third dog. Clearance from the nasal region was insignificant. Clearance half-time from the second generation bronchus was 200 seconds; from the seventh generation bronchus it was 110 seconds.
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