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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Range-finding toxicity data: List VII
Author:
Smyth HF jr, Carpenter CP, Weil CS, Pozzani UC, Striegel JA & Nycum JS
Year:
1969
Bibliographic source:
Am Ind Hyg Assoc J. 1969 Sep-Oct; 30(5):470-6
Reference Type:
secondary source
Title:
SULFURIC ACID CAS No. 7664-93-9: SIDS Initial Assessment Report for 11th SIAM
Author:
OECD
Year:
2001
Bibliographic source:
UNEP Publications

Materials and methods

Test guideline
Qualifier:
no guideline followed
Deviations:
not applicable
Principles of method if other than guideline:
The study was performed as part of a series of 'range-finding' tests performed with a large number of industrial chemicals. The protocol for acute oral toxicity is broadly similar to OECD 401 in that groups of rats were gavaged with a single dose of the test material and observed for 14 days.
GLP compliance:
no
Remarks:
: the study pre-dates GLP.
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sulphuric acid
EC Number:
231-639-5
EC Name:
Sulphuric acid
Cas Number:
7664-93-9
Molecular formula:
H2O4S
IUPAC Name:
sulfuric acid
Details on test material:
The test material is described as reagent grade sulphuric acid, whic implies 95-98% sulphuric acid.

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
A logarithmic series of doses were used, but are not reported. Sulphuric acid was administered in water at 0.25 g/ml.
No. of animals per sex per dose:
Five animals of a single sex were used
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 140 mg/kg bw
95% CL:
>= 1 540 - <= 2 990

Any other information on results incl. tables

Only limited details of the results for individual chemicals are reported in this study, which reports basic toxicity screening data for a large nunber of chemicals.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The results of this study indicate that sulphuric acid is of low acute oral toxicity when gastric intubation is used as the method of administration. Sulphuric acid is not classified for acute oral toxicity according to current EU criteria.
Executive summary:

Unfasted Carworth-Wistar rats (5 of a single sex per dose group) were gavaged with sulphuric acid and observed for 14 days. Based on the pattern of mortalities, the 'most probable median lethal dose' is reported to be 2140 (1540 -2990) mg/kg bw.

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