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EC number: 248-299-9
CAS number: 27178-16-1
Table 1: Foetal defects and variants - Intergroup comparison of
foetal defects and variants
Dietary conc. of DEHA (ppm)
No. of litters examined
External and visceral defects
No. of foetuses examined
No. of foetuses showing major defects
No. of foetuses showing minor defects only
No. of foetuses showing variants
Table 2: Summary of the type and incidence of major defects
Situs inversus totalis
Left adrenal, kidney and ureter absent
Cysts attached to liver
Small right kidney
Skull: Multiple minor defects
3rdand 7thribs (left) not ossified0
1strib (right) partially ossified
There was no evidence that the test substance is teratogenic to
the rat at any of the dose levels tested (up to 12000 ppm -approximately
1000 mg/kg/day). Administration of 12000 ppm DEHA resulted in slight
maternal toxicity and slight foetotoxicity.
At 1800 ppm, there was no evidence of maternal toxicity although
minimal foetotoxicity was observed. A dietary level of 300 ppm DEHA was
a clear no-effect level for embryonic development.
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