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Administrative data

Description of key information

Read-across substance, bis(2-ethylhexyl) adipate, was determined to be not a skin sensitiser based on the results of a QSAR assessment (OASIS Times Mix 2.26.3).

Read-across substance, diisononyl adipate, was determined to be not a skin sensitiser based on the results of a QSAR assessment (OASIS Times Mix 2.26.3).

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records

Referenceopen allclose all

Endpoint:
skin sensitisation, other
Remarks:
QSAR
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Justification for type of information:
Please see Section 13 below.
Reason / purpose for cross-reference:
read-across source
Key result
Run / experiment:
other:
Parameter:
other: QSAR
Remarks on result:
other: he QSAR program calculated a negative sensitization potential of the test substance.
Interpretation of results:
GHS criteria not met
Endpoint:
skin sensitisation, other
Remarks:
QSAR
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Justification for type of information:
Please see Section 13 below.
Reason / purpose for cross-reference:
read-across source
Key result
Run / experiment:
other:
Parameter:
other: QSAR
Remarks on result:
other: The QSAR program calculated a negative sensitization potential of the test substance.
Interpretation of results:
GHS criteria not met
Endpoint:
skin sensitisation, other
Remarks:
QSAR
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Validated QSAR System-Substance is in domain of the system.
Justification for type of information:
QSAR prediction
Validated QSAR System-Substance is in domain of the system.
Principles of method if other than guideline:
A quantitive structure-activity relationship (QSAR) system for the estimation of the skin sensitization potency that incorporates skin metabolism and consideres the potential of parent chemicals and/or their activated metabolites to react with skin proteins. A chemically divers training set was used and their skin sensitization potency assigned to one of three classes.
GLP compliance:
no
Key result
Run / experiment:
other:
Parameter:
other: QSAR
Remarks on result:
other: The QSAR program calculated a negative sensitization potential of the test substance.

A stimulation index neither animals no. with + reactions could not be derived, as a QSAR was used that predicted the test substance as not sensitizing.

Interpretation of results:
GHS criteria not met
Endpoint:
skin sensitisation, other
Remarks:
other: Calculated
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Validated QSAR System-Substance is in domain of the system.
Justification for type of information:
QSAR prediction
Validated QSAR System-Substance is in domain of the system.
Qualifier:
no guideline available
Principles of method if other than guideline:
A quantitive structure-activity relationship (QSAR) system for the estimation of the skin sensitization potency that incorporates skin metabolism and consideres the potential of parent chemicals and/or their activated metabolites to react with skin proteins. A chemically divers training set was used and their skin sensitization potency assigned to one of three classes.
GLP compliance:
no
Key result
Run / experiment:
other:
Parameter:
other: QSAR
Remarks on result:
other: The QSAR program calculated a negative sensitization potential of the test substance.

The QSAR program calculated a negative sensitization potential of the test substance.

Interpretation of results:
GHS criteria not met
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the above mentioned results, classification according to the CLP Regulation (EC) 1272/2008 is not necessary.