Registration Dossier
Registration Dossier
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EC number: 248-299-9 | CAS number: 27178-16-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- other: Calculated
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Validated QSAR System-Substance is in domain of the system.
- Justification for type of information:
- QSAR prediction
Validated QSAR System-Substance is in domain of the system.
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- A quantitive structure-activity relationship (QSAR) system for the estimation of the skin sensitization potency that incorporates skin metabolism and consideres the potential of parent chemicals and/or their activated metabolites to react with skin proteins. A chemically divers training set was used and their skin sensitization potency assigned to one of three classes.
- GLP compliance:
- no
Test material
- Reference substance name:
- Diisononyl adipate
- EC Number:
- 251-646-7
- EC Name:
- Diisononyl adipate
- Cas Number:
- 33703-08-1
- IUPAC Name:
- bis(7-methyloctyl) adipate
- Details on test material:
- no data
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Key result
- Run / experiment:
- other:
- Parameter:
- other: QSAR
- Remarks on result:
- other: The QSAR program calculated a negative sensitization potential of the test substance.
Any other information on results incl. tables
The QSAR program calculated a negative sensitization potential of the test substance.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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