Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-299-9 | CAS number: 27178-16-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- other: Calculated
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Validated QSAR System-Substance is in domain of the system.
- Justification for type of information:
- QSAR prediction
Validated QSAR System-Substance is in domain of the system.
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- A quantitive structure-activity relationship (QSAR) system for the estimation of the skin sensitization potency that incorporates skin metabolism and consideres the potential of parent chemicals and/or their activated metabolites to react with skin proteins. A chemically divers training set was used and their skin sensitization potency assigned to one of three classes.
- GLP compliance:
- no
Test material
- Reference substance name:
- Diisononyl adipate
- EC Number:
- 251-646-7
- EC Name:
- Diisononyl adipate
- Cas Number:
- 33703-08-1
- IUPAC Name:
- bis(7-methyloctyl) adipate
- Details on test material:
- no data
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Key result
- Run / experiment:
- other:
- Parameter:
- other: QSAR
- Remarks on result:
- other: The QSAR program calculated a negative sensitization potential of the test substance.
Any other information on results incl. tables
The QSAR program calculated a negative sensitization potential of the test substance.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
