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EC number: 231-391-8 | CAS number: 7529-22-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Additional physico-chemical information
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- Endpoint summary
- Stability
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
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- Additional toxicological data

Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 March 2012 - 04 April 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent/transformation products: 0, 24, 120 and 144h
- Sampling method: not specified
- Sampling intervals/times for pH measurements: 0, 24, 120 and 144h
- Sampling intervals/times for sterility check: no further sterility checks done
- Sample storage conditions before analysis: not specified
- Other observation, if any (e.g.: precipitation, color change etc.): no other observations reported - Buffers:
- - pH: 4, 7, 9
- Type and final molarity of buffer: potassium hydrogen phthalate (pH 4; 5 mmol/L); disodium hydrogen orthophosphate (anhydrous, 3 mmol/L) / potassium dihydrogen orthophosphate (2 mmol/L) / sodium chloride (2 mmol/L) pH 7; disodium tetraborate (1 mmol/L) / sodium chloride (2 mmol/L) pH 9. - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks, other equipment used: stoppered glass flasks
- Sterilisation method: buffer solutions were sterilised; not further specified
- Lighting: flasks were shielded from light
- Measures to exclude oxygen: treatment of buffer solutions: ultrasonication and degassing with nitrogen
- If no traps were used, is the test system closed/open: closed
- Is there any indication of the test material adsorbing to the walls of the test apparatus?: no - Duration:
- 144 h
- Temp.:
- 50 °C
- Initial conc. measured:
- 0.9 - 1.1 g/L
- Number of replicates:
- Individual vessels were used for each data point.
- Positive controls:
- no
- Negative controls:
- no
- Statistical methods:
- Not applicable
- Preliminary study:
- The preliminary test revealed that the substance is hydrolytically stable. No further test was performed.
- Transformation products:
- no
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- Details on results:
- At all three pH values there was less than 10% degradation observed over a 5-days period at 50°C. This is equivalent to an extrapolated half-life time at 25 °C of > 1 year).
- Validity criteria fulfilled:
- yes
- Conclusions:
- The substance is concluded to be hydrolytically stable under the conditions of the test. Extrapolated half-life time at 25 °C: > 1 year.
- Executive summary:
Hydrolysis of N-methylmorpholine oxide at 0.6 -1.1 g/L was studied shielded from light at 50 °C in aqueous buffered solutions at pH 4 (potassium hydrogen phthalate, 5 mmol/L), 7 (disodium hydrogen orthophosphate, anhydrous, 3 mmol/L / potassium dihydrogen orthophosphate, 2 mmol/L / sodium chloride, 2 mmol/L) and 9 (disodium tetraborate, 1 mmol/L / sodium chloride, 2 mmol/L) for 6 days. the experiment was conducted in accordance with the OECD guideline 111, and in compliance with GLP standards. Samples were analysed at 0, 1, 5 and 6 days. Details on analytical methods are not available.
At test termination the concentration of the parent compound decreased by less than 10% from day 0 at every pH tested.
The half-life/DT50 (50% decline time) of N-methylmorpholine oxide was > 1 year at every pH tested (4, 7 and 9).
The study is classified acceptable and satisfies the guideline requirements for hydrolysis study.
Reference
Description of key information
The key value for hydrolysis was obtained from a 5-day preliminary test at pH 4, 7 and 9 and 50 °C. In this GLP test in accordance with OECD Test Guideline 111 no significant (< 10%) degradation was observed (Walker, 2012).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 25 °C
Additional information
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