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EC number: 629-661-9 | CAS number: 83834-59-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- Potamopyrgus antipodarum: concentration range is too low. Significance of the effect at higher concentration is not convincing in view of the high variability of the number of embryos; no information on number of replicates (Rel 3). For the remaining invertebrate species: limited details and high intervals between test concentrations (factor of 5) potentially resulting in a relatively low NOEC, variable measured exposure concentrations.For zebra fish/bacteria, high intervals between test concentrations (factor of 10), no analytics (additional details are provided in the attached evaluation dcoument)
Data source
Reference
- Reference Type:
- publication
- Title:
- Ecotoxicological effect characterisation of widely used organic UV filters
- Author:
- Kaiser et al.
- Year:
- 2 012
- Bibliographic source:
- Environmental Pollution, Volume 163, 2012, Pages 84-90,
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OECD guideline 225
- Version / remarks:
- 2007
- Deviations:
- yes
- Remarks:
- sediment contained 99.6% pure quartz sand (grain size 0.1e0.4, Quick Mix group, Osnabrück, Germany) and 0.4% grounded alder leaves (Alnus glutinosa)
- Qualifier:
- according to guideline
- Guideline:
- other: OECD guideline 218
- Version / remarks:
- 2004
- Deviations:
- yes
- Remarks:
- sediment contained 99.6% pure quartz sand (grain size 0.1e0.4, Quick Mix group, Osnabrück, Germany) and 0.4% grounded alder leaves (Alnus glutinosa)
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38415-6
- Version / remarks:
- 2001
- Deviations:
- not specified
- Remarks:
- in addition the methods given in Nagel (2002) and Lammer et al. (2009) were applied
- Principles of method if other than guideline:
- The 56 day sediment test with Potamopyrgus antipodarum was performed following the method described in Duft et al. (2007) with deviations.
The sediment contact test with Danio rerio was carried out according to the German guideline DIN 38415-6. In addition, the methods given in Nagel (2002) and Lammer et al. (2009) were applied.
For the 28 day sediment test with Melanoides tuberculata no official guideline was available. The applied method is described in the present publication (Kaiser et al., 2012).
References:
Duft, M., Schmitt, C., Bachmann, J., Brandelik, C., Schulte-Oehlmann, U., Oehlmann, J.,
2007. Prosobranch snails as test organisms for the assessment of endocrine active
chemicals e an overview and a guideline proposal for a reproduction test with
the freshwater mudsnail Potamopyrgus antipodarum. Ecotoxicology 16,169-182.
Lammer, E., Carr, G.J., Wendler, K., Rawlings, J.M., Belanger, S.E., Braunbeck, T., 2009.
Is the fish embryo toxicity test (FET) with the zebrafish (Danio rerio) a potential
alternative for the fish acute toxicity test? Comp. Biochem. Phys. C 149.
Nagel, R., 2002. DarT: the embryo test with the Zebrafish Danio rerioea general
model in ecotoxicology and toxicology. Altex 19 (Suppl. 1), 38e48.
196-209. - GLP compliance:
- not specified
Test material
- Reference substance name:
- (2R)-2-ethylhexyl (2E)-3-(4-methoxyphenyl)prop-2-enoate; (2S)-2-ethylhexyl (2E)-3-(4-methoxyphenyl)prop-2-enoate
- EC Number:
- 629-661-9
- Cas Number:
- 83834-59-7
- Molecular formula:
- C18H26O3
- IUPAC Name:
- (2R)-2-ethylhexyl (2E)-3-(4-methoxyphenyl)prop-2-enoate; (2S)-2-ethylhexyl (2E)-3-(4-methoxyphenyl)prop-2-enoate
- Test material form:
- liquid
- Details on test material:
- Details on test material not reported
Constituent 1
- Specific details on test material used for the study:
- no purity nor impurities specified
no information on storage stability, expiry date etc
Results and discussion
Any other information on results incl. tables
Table 1: Nominal and measured test concentrations of EHMC at the beginning and the end (in brackets) of the sediment tests with Chironomus riparius, Lumbriculus variegatus, Melanoides tuberculata and Potamopyrgus antipodarum (C = control; SC = solvent control; n.d. = not detectable; - = not tested or not measured).
Nominal concentration [mg/kg dw] |
EHMC [mg/kg dw] |
|||
|
C. riparius |
L. variegatus |
M. tuberculata |
P. antipodarum |
C |
n.d. (n.d.) |
n.d. (n.d.) |
n.d. (n.d.) |
n.d. (n.d.) |
SC |
n.d. (n.d.) |
n.d. (n.d.) |
n.d. (n.d.) |
n.d. (n.d.) |
0.00064 |
- |
- |
- |
0.0012 (0.0008) |
0.016 |
- |
- |
- |
0.018 (0.013) |
0.08 |
0.04 (0.04) |
0.01 (0.01) |
0.11 (0.10) |
- |
0.4 |
- |
- |
- |
0.25 (0.18) |
50.0 |
46.4 (40.8) |
33.4 (30.9) |
52.4 (43.6) |
- |
Table 2: Chironomus riparius. Effects of EHMC on mortality and mean emergence time after 28 days of exposure via sediments. Values represent mean values ± SD of 5 replicates. Lumbriculus variegatus. Effects of EHMC on number of annelids and biomass after 28 days of exposure via sediments. Values represent mean values ± SD of 4 replicates. Arthrobacter globiformis. Effects of EHMC on dehydrogenase activity (dha) after 48 h of exposure via sediments. Values represent mean values of four replicates compared to solvent control. C = control. - = not tested.
EHMC [mg/kg dw] |
C. riparius |
L. variegatus |
A. globiformis | |||
Mortality [%] | EMT50 Males [d] | EMT50 Females [d] | Number of Annelids | Biomass [mg] | Inhibition of dha [%] | |
C | 3.3 ± 5.9 | 17.1 ± 0.69 | 20.2 ± 0.47 | 45.1 ± 5.48 | 0.81 ± 0.09 | - |
0.08 | 0 | 17.8 ± 1.32 | 21.3 ± 1.40 | 48.5 ± 3.51 | 0.90 ± 0.22 | - |
0.4 | 5.0 ± 6.1 | 17.4 ± 0.68 | 20.8 ± 0.69 | 43.5 ± 6.25 | 0.98 ± 0.15 | - |
2.0 | 4.0 ± 4.2 | 17.4 ± 0.39 | 21.7 ± 0.88 | 44.0 ± 4.24 | 0.95 ± 0.17 | - |
10.0 | 4.0 ± 5.5 | 17.9 ± 0.80 | 21.4 ± 1.50 | 42.5 ± 3.87 | 0.78 ± 0.09 | 23.9 |
50.0 | 4.0 ± 4.2 | 17.6 ± 0.62 | 21.6 ± 1.01 | 40.8 ± 8.50 | 0.85 ± 0.17 | - |
100 | - | - | - | - | - | 12.3 |
1000 | - | - | - | - | - | -13.08 |
EFFECT CONCENTRATIONS
28d-NOEC M. tuberculate: 2 mg/kg ds
28d-LOEC M. tuberculate: 10 mg/kg ds
28d-NOEC L. variegatus: ≥ 50 mg/kg dw ds
28d-NOEC C. riparius: ≥ 50 mg/kg dw ds
56d-NOEC P. antipodarum: ≥ 0.4 mg/kg ds
3h-NOEC A. globiformis: ≥ 1000 mg/kg
48h-NOEC D. rerio (mortality): ≥ 1000 mg/kg
48h-NOEC D. rerio (sub-lethal): 100 mg/kg
48h-LOEC D. rerio (sub-lethal): 1000 mg/kg
Applicant's summary and conclusion
- Conclusions:
- The results of the publication are regarded as not reliable with regard to derivation of the PNEC for sediment organism.
- Executive summary:
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