Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
3 µg/L
Assessment factor:
10
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
0.271 µg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.3 µg/L
Assessment factor:
100
Extrapolation method:
assessment factor
PNEC marine water (intermittent releases):
0.271 µg/L

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
100 mg/L
Assessment factor:
10
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
insufficient hazard data available (further information necessary)

Sediment (marine water)

Hazard assessment conclusion:
insufficient hazard data available (further information necessary)

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
no exposure of soil expected

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Table: Overview about relevant study results

Guideline

Test species

Endpoint

Result

Remarks

OECD 203

Cyprinus carpio

96h-LL50

96h-LC50

> 100 (nominal)

0.7- 0.075 (measured)

no effect up to and including the water solubility limit

Key study
GLP, rel.1

OECD 203

Danio rerio

96h-LC50

1216.1 mg/L**

Supporting study
GLP, rel. 1

OECD 234

Danio rerio

63d-NOEC

63d-LOEC

< 46.9 µg/L (measured)

46.9 µg/L (measured)

Key study

GLP, rel. 1

OECD 210 (modified)

Danio rerio

21d-NOEC

≥ 30 µg/L (measured)

Supporting study

non-GLP, rel.1

OECD 202

Daphnia magna

48h-EL50

48h-EC50

> 100 mg/L (nominal)

> 0.0271 (measured)

no effect up to and including the water solubility limit

Key study

GLP, rel. 1

OECD 211

Daphnia magna

21d-EL10

> 60 μg/L (nominal)

no effect up to and including the water solubility limit

Key study

GLP, rel. 1

OECD 201

Pseudokirchneriella
subcapitata

*72h- NOEL growth
*72h-EL50 growth

> 32 mg/L (nominal)

> 100 mg/L (nominal)
(meas. < 0.001)

no effect up to and including the water solubility limit

Key study
GLP, rel.1

OECD 201

Scenedesmus subspicatus
= Desmodesmus
subspicatus

72h-EL10
72h-EL50

> 100 mg/L

> 100 mg/L
Not measured

no effect up to and including the water solubility limit

Supporting study
GLP, rel. 1

OECD 221

Lemna minor

7d-EC50

7d-NOEC

> 0.06 mg/L (measured TWA)

> 0.06 mg/L (measured TWA)

no effect up to and including the water solubility limit

Key study

GLP, rel. 1

OECD 209

Activated sludge (domestic)

30 min-NOEC

> 1000 mg/L (nominal)
Not measured

Key study

no GLP, rel. 1

OECD 231

Xenopus laevis

21d-NOEC

≥ 44.2 µg/L (measured)

Key study

GLP, rel. 1

* 24-h Pre-exposure period in the dark in view of photodegradability of the test substance. Test conc. after 96 h (is after 72 h of light) < 0.001 mg/L.
** This measured concentration is far above the water solubility limit.

Conclusion on classification

Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008

Classification related information

Readily biodegradable: 78 % (BOD) in 28 days, 10-day window met (OECD TG 301F)

Ultimately anaerobically biodegradable: plateau at 67 % after 79 days (ISO 11734: 1995)

Log Pow: > 6 at 23 °C

 

Aquatic acute toxicity

Fish: LL50 (96 h) > 100 mg/L (nominal, Cyprinus carpio,, OECD 203)

Invertebrates: EL50 (48 h) > 100 mg/L (nominal, Daphnia magna, equivalent to OECD 202)

Algae: ErL50 (72 h) > 100 mg/L (nominal, Pseudokirchneriella subcapitata, OECD 201)

Aquatic plants: EC50 (7 d) > 0.06 mg/L (measured TWA, Lemna minor, OECD 221)

 

Aquatic chronic toxicity

Fish: NOEC (72 h) ≥ 30 µg/L (measured, Danio rerio, OECD 210, modified)

Invertebrates: NOEL (21 d) ≥ 60 µg/L (nominal, Daphnia magna, OECD 211)

Algae: ErL10 (72 h) > 100 mg/L (nominal, Pseudokirchneriella subcapitata, OECD 201) 

Aquatic plants: NOEC (7 d, growth rate) > 0.06 mg/L (measured TWA, Lemna minor, OECD 221)

 

Conclusion

The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008. The substance 2-ethylhexyl trans-4-methoxycinnamate (OMC) is rapidly degraded. The short-term toxicity studies for algae, daphnia and fish resulted in no short-term (acute) aquatic toxicity within the limit of water solubility. The lowest long-term result of NOEC (72 h) ≥ 30 µg/L was determined for the freshwater fish Danio rerio. The log Pow was determined to be > 6 at 23 °C. Based on these results, OMC is not classified for aquatic short-term (acute) toxicity, but for aquatic long-term (chronic) toxicity Category 2 (H411: Toxic to aquatic life with long lasting effects) according to Regulation (EC) No 1272/2008 (CLP), as amended for the 17th time in Regulation (EU) 2021/849.