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EC number: 629-661-9 | CAS number: 83834-59-7
Percentage of substance absorbed after 24 hrs:
1 % in carbitol: 44.3 %
3 % in carbitol: 35.6 %
10 % in carbitol: 22.7 %
About 70 - 90 % of the applied dose of Ethylhexyl Methoxycinnamate was found on the skin surface during the first 6 hours after application
The amount recovered from the stratum corneum was low and reached its maximum 24 hours after application. The steady state was attained within 6 hours.
The portion of Ethylhexyl Methoxycinnamate found in the stripped skin increased to its maximum within 16 hours. Lower levels of the test material were found 24 hours after application.
A significant part of the applied dose was found in the chamber liquid (7 - 17 %) after longer times of exposure.
Skin penetrating potential of Ethylhexyl Methoxycinnamate in naked rat skin was determined in a study using an in vitro system. The study was performed according to an equivalent of OECD guideline 428. Three concentrations of Ethylhexyl Methoxycinnamate in carbitol (1, 3 and 10 %) were applied and skin absorption rates were determined by the activity of the 14C-labelled test article.
It was found that the higher amount of Ethylhexyl Methoxycinnamate is absorbed into the upper layer of the skin (stripped skin). The low levels in the stratum corneum and the amount of activity recovered from the chamber liquid indicate significant penetration and resorption capacities of Ethylhexyl Methoxycinnamate through the intact skin of the naked rat after longer times of exposure.
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