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EC number: 629-661-9 | CAS number: 83834-59-7
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP guideline study
- Qualifier:
- according to
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0.041 mg/L
- Temp.:
- 24 °C
- pH:
- 7.1
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 09/02/2000 - 11/05/2000
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study according to international guideline (OECD Guideline 105) under GLP conditions, validity criteria met.
- Qualifier:
- according to
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. certificate)
- Type of method:
- flask method
- Key result
- Water solubility:
- >= 0.22 - <= 0.75 mg/L
- Temp.:
- 21 °C
- pH:
- >= 7.2 - <= 7.6
- Conclusions:
- The water solubility of 2-Ethylhexyl 4-methoxycinnamate was investigated according to OECD Guideline 105 and was found to be 0.22 - 0.75 mg/l at 21 °C using the flask method.
- Executive summary:
Water solubility of 2-Ethylhexyl 4-methoxycinnamate was investigated according to OECD Guideline 105 (flask method) under GLP conditions. The 24-, 48- and 72-hour measurements were not in agreement. Therefore, the water solubility test was prolonged with 96 hours. The 120-, 144- and 168-hour measurements were not in agreement. Therefore, the water solubility test was prolonged to 12, 13 or 14 days of stirring. The 12-, 13- and 14-days measurements were not in agreement. Therefore, the water solubility of 2-Ethylhexyl 4-methoxycinnamate was reported as a range based on all measurements. In conclusion, the water solubility of 2-Ethylhexyl 4-methoxycinnamate at 21.0 ± 1.0 °C is between 0.22 and 0.75 mg/L, using the flask method.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24/05/2018- 22/08/2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. certificate)
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0.051 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 6.7
- Remarks on result:
- other:
- Remarks:
- demineralized water
- Executive summary:
The water solubility of the test item in demin . water is 51 µg/L ± 5 µg/L at T = 20.0 °C ± 0.5 °C.
Referenceopen allclose all
The 24-, 48- and 72 -hour measurements were not in agreement. Therefore, the water solubility test was prolonged with 96 hours. The 120-, 144- and 168-hour measurements were not in agreement. Therefore, the water solubility test was prolonged to 12, 13 or 14 days of stirring. The 12-, 13- and 14-days measurements were not in agreement. Therefore, the water solubility of 2-ethylhexyl 4-methoxycinnamate is reported as a range based on all measurements. In conclusion, the water solubility of 2 -ethylhexyl 4-methoxycinnamateat 21.0 ± 1.0 °C is between 0.22 and 0.75 mg/L, using the flask method.
Description of key information
Water solubility: 0.051 ± 0.005 mg/L (20 ± 0.5 °C)
Key value for chemical safety assessment
- Water solubility:
- 0.051 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility in demineralized water was determined in a key study (2018) according to OECD 105 under GLP. The reported water solubility was determined to be 0.051 ± 0.005 mg/L (20 ± 0.5 °C).
The aqueous solubility of Ethylhexyl Methoxycinnamate was also determined under test conditions in a Fish sexual development test (OECD 234) and an Amphibian Metamorphosis Assay (OECD 231). The actual measured aqueous solubility was determined to be 0.049 mg/L (22°C) and 0.048 mg/L at test conditions in the OECD 231 and OECD 234 study, respectively.
Another supporting study reported a water solubility of 0.041 mg/L at 24 °C using the column elution method according to an international guideline under GLP. In a third study, the water solubility of Ethylhexyl Methoxycinnamate was determined to be 0.22 - 0.75 mg/L at 21 °C (2000).
However this study was disregarded for relibiability as the used method is not recommended by the guideline for poorly water soluble substances with a water solubility below 0.01g/L.
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