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Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
GLP guideline study
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes
Type of method:
column elution method
Key result
Water solubility:
0.041 mg/L
Temp.:
24 °C
pH:
7.1
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
09/02/2000 - 11/05/2000
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Study according to international guideline (OECD Guideline 105) under GLP conditions, validity criteria met.
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Key result
Water solubility:
>= 0.22 - <= 0.75 mg/L
Temp.:
21 °C
pH:
>= 7.2 - <= 7.6

The 24-, 48- and 72 -hour measurements were not in agreement. Therefore, the water solubility test was prolonged with 96 hours. The 120-, 144- and 168-hour measurements were not in agreement. Therefore, the water solubility test was prolonged to 12, 13 or 14 days of stirring. The 12-, 13- and 14-days measurements were not in agreement. Therefore, the water solubility of 2-ethylhexyl 4-methoxycinnamate is reported as a range based on all measurements. In conclusion, the water solubility of 2 -ethylhexyl 4-methoxycinnamateat 21.0 ± 1.0 °C is between 0.22 and 0.75 mg/L, using the flask method.

Conclusions:
The water solubility of 2-Ethylhexyl 4-methoxycinnamate was investigated according to OECD Guideline 105 and was found to be 0.22 - 0.75 mg/l at 21 °C using the flask method.
Executive summary:

Water solubility of 2-Ethylhexyl 4-methoxycinnamate was investigated according to OECD Guideline 105 (flask method) under GLP conditions. The 24-, 48- and 72-hour measurements were not in agreement. Therefore, the water solubility test was prolonged with 96 hours. The 120-, 144- and 168-hour measurements were not in agreement. Therefore, the water solubility test was prolonged to 12, 13 or 14 days of stirring. The 12-, 13- and 14-days measurements were not in agreement. Therefore, the water solubility of 2-Ethylhexyl 4-methoxycinnamate was reported as a range based on all measurements. In conclusion, the water solubility of 2-Ethylhexyl 4-methoxycinnamate at 21.0 ± 1.0 °C is between 0.22 and 0.75 mg/L, using the flask method.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24/05/2018- 22/08/2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
yes (incl. certificate)
Type of method:
column elution method
Key result
Water solubility:
0.051 mg/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
6.7
Remarks on result:
other:
Remarks:
demineralized water
Executive summary:

The water solubility of the test item in demin . water is 51 µg/L ± 5 µg/L at T = 20.0 °C ± 0.5 °C.

Description of key information

Water solubility: 0.051 ± 0.005 mg/L (20 ± 0.5 °C)

Key value for chemical safety assessment

Water solubility:
0.051 mg/L
at the temperature of:
20 °C

Additional information

The water solubility in demineralized water was determined in a key study (2018) according to OECD 105 under GLP. The reported water solubility was determined to be 0.051 ± 0.005 mg/L (20 ± 0.5 °C).

The aqueous solubility of Ethylhexyl Methoxycinnamate was also determined under test conditions in a Fish sexual development test (OECD 234) and an Amphibian Metamorphosis Assay (OECD 231). The actual measured aqueous solubility was determined to be 0.049 mg/L (22°C) and 0.048 mg/L at test conditions in the OECD 231 and OECD 234 study, respectively.

Another supporting study reported a water solubility of 0.041 mg/L at 24 °C using the column elution method according to an international guideline under GLP. In a third study, the water solubility of Ethylhexyl Methoxycinnamate was determined to be 0.22 - 0.75 mg/L at 21 °C (2000).

However this study was disregarded for relibiability as the used method is not recommended by the guideline for poorly water soluble substances with a water solubility below 0.01g/L.