Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 629-661-9 | CAS number: 83834-59-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP guideline study
- Qualifier:
- according to
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0.041 mg/L
- Temp.:
- 24 °C
- pH:
- 7.1
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 09/02/2000 - 11/05/2000
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study according to international guideline (OECD Guideline 105) under GLP conditions, validity criteria met.
- Qualifier:
- according to
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. certificate)
- Type of method:
- flask method
- Key result
- Water solubility:
- >= 0.22 - <= 0.75 mg/L
- Temp.:
- 21 °C
- pH:
- >= 7.2 - <= 7.6
- Conclusions:
- The water solubility of 2-Ethylhexyl 4-methoxycinnamate was investigated according to OECD Guideline 105 and was found to be 0.22 - 0.75 mg/l at 21 °C using the flask method.
- Executive summary:
Water solubility of 2-Ethylhexyl 4-methoxycinnamate was investigated according to OECD Guideline 105 (flask method) under GLP conditions. The 24-, 48- and 72-hour measurements were not in agreement. Therefore, the water solubility test was prolonged with 96 hours. The 120-, 144- and 168-hour measurements were not in agreement. Therefore, the water solubility test was prolonged to 12, 13 or 14 days of stirring. The 12-, 13- and 14-days measurements were not in agreement. Therefore, the water solubility of 2-Ethylhexyl 4-methoxycinnamate was reported as a range based on all measurements. In conclusion, the water solubility of 2-Ethylhexyl 4-methoxycinnamate at 21.0 ± 1.0 °C is between 0.22 and 0.75 mg/L, using the flask method.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24/05/2018- 22/08/2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. certificate)
- Type of method:
- column elution method
- Key result
- Water solubility:
- 0.051 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 6.7
- Remarks on result:
- other:
- Remarks:
- demineralized water
- Executive summary:
The water solubility of the test item in demin . water is 51 µg/L ± 5 µg/L at T = 20.0 °C ± 0.5 °C.
Referenceopen allclose all
The 24-, 48- and 72 -hour measurements were not in agreement. Therefore, the water solubility test was prolonged with 96 hours. The 120-, 144- and 168-hour measurements were not in agreement. Therefore, the water solubility test was prolonged to 12, 13 or 14 days of stirring. The 12-, 13- and 14-days measurements were not in agreement. Therefore, the water solubility of 2-ethylhexyl 4-methoxycinnamate is reported as a range based on all measurements. In conclusion, the water solubility of 2 -ethylhexyl 4-methoxycinnamateat 21.0 ± 1.0 °C is between 0.22 and 0.75 mg/L, using the flask method.
Description of key information
Water solubility: 0.051 ± 0.005 mg/L (20 ± 0.5 °C)
Key value for chemical safety assessment
- Water solubility:
- 0.051 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility in demineralized water was determined in a key study (2018) according to OECD 105 under GLP. The reported water solubility was determined to be 0.051 ± 0.005 mg/L (20 ± 0.5 °C).
The aqueous solubility of Ethylhexyl Methoxycinnamate was also determined under test conditions in a Fish sexual development test (OECD 234) and an Amphibian Metamorphosis Assay (OECD 231). The actual measured aqueous solubility was determined to be 0.049 mg/L (22°C) and 0.048 mg/L at test conditions in the OECD 231 and OECD 234 study, respectively.
Another supporting study reported a water solubility of 0.041 mg/L at 24 °C using the column elution method according to an international guideline under GLP. In a third study, the water solubility of Ethylhexyl Methoxycinnamate was determined to be 0.22 - 0.75 mg/L at 21 °C (2000).
However this study was disregarded for relibiability as the used method is not recommended by the guideline for poorly water soluble substances with a water solubility below 0.01g/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

Route: .live2