Manganese dioxide

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Justification for type of information:

In accordance with Column 2 of REACH Annex VIII, acute toxicity testing by the dermal route is not appropriate as the physicochemical and toxicological properties do not suggest potential for a significant rate of absorption through the skin. The substance is practically insoluble in water and inorganic ions do not pass easily through the dermal barrier. In particular the high charge on the Mn4+ cation would have great difficulty in penetrating the skin.