Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Oral

In accordance with Section 1 of REACH Annex XI, testing does not appear to be scientifically necessary; manganese dioxide is included in Annex VI of Regulation (EC) No 1272/2008 (CLP Regulation) and is classified as acutely harmful by the oral route although there is no study available to justify this level of toxicity. Therefore, no further testing is proposed on animal welfare grounds and this classification is carried forward for risk assessment purposes.

 

Inhalation

In accordance with Section 1 of REACH Annex XI, testing does not appear to be scientifically necessary; manganese dioxide is included in Annex VI of Regulation (EC) No 1272/2008 (CLP Regulation) and is classified as acutely harmful by the inhalation route although there is no study available to justify this level of toxicity. Therefore, no further testing is proposed on animal welfare grounds and this classification is carried forward for risk assessment purposes.

 

Dermal

In accordance with Column 2 of REACH Annex VIII, acute toxicity testing by the dermal route is not appropriate as the physicochemical and toxicological properties do not suggest potential for a significant rate of absorption through the skin. The substance is practically insoluble in water and inorganic ions do not pass easily through the dermal barrier. In particular the high charge on the Mn4+ cation would have great difficulty in penetrating the skin.

Justification for classification or non-classification

In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No. 1272/2008, the substance is classified as acutely harmful by the oral and inhalation routes and has the following hazard phrases: H302 - Harmful if swallowed, and H332 - Harmful if inhaled.

No classification for the dermal route is required based on the very low dermal absorption expected for MnO2.