Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-202-6 | CAS number: 1313-13-9
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not conducted to GLP or standard methodology, follows basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Contact dermatitis and contact sensitisation among enamellers and decorators in the ceramics industry
- Author:
- Motolese A, Truzzi M, Giannini A and Seidenari S
- Year:
- 1 993
- Bibliographic source:
- Contact Dermatitis, 28:59-62
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 190 workers (119 females and 71 males) from 5 ceramics factories underwent dermatological and allergological examination using occupational test series. Manganese dioxide was used as a 10% in petrol. Patch tests were applied to healthy skin on the back, removed after 2 days and read 1 day later.
- GLP compliance:
- no
Test material
- Reference substance name:
- Manganese dioxide
- EC Number:
- 215-202-6
- EC Name:
- Manganese dioxide
- Cas Number:
- 1313-13-9
- Molecular formula:
- MnO2
- IUPAC Name:
- dioxomanganese
Constituent 1
Method
- Ethical approval:
- not specified
- Subjects:
- All subjects work within the ceramic industry and are exposed to chemicals such as manganese dioxide on a daily basis.
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- NO. OF PERSONS WITH/OUT REACTIONS COMPARED TO STUDY POPULATION
- Number of subjects with positive reactions:2
OTHER RESULTS: contact dermatitis was also present
Applicant's summary and conclusion
- Conclusions:
- Two people out of 190 tested with MnO2 showed an effect, compared to 28 out of 190 for NiSO4 which is regarded as a sensitiser. The small number is not regarded as substantial, as would be required by CLP in order to trigger classification. It is also much less then the NiSO4. It is considered therefore that this result supports the negative LLNA result for this substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
